Nacionalni portal odprte znanosti

Receptor NOD2 je pomembna komponenta prirojenega imunskega sistema in je zato zanimiva tarča za iskanje novih imunomodulatorjev. NOD2 sicer spada med znotrajcelične receptorje za prepoznavo vzorcev, ki zaznavajo metabolite peptidoglikana - ta se nahaja v celični steni tako Gram pozitivnih kot Gram n ...

The everyday use of household and personal care products (HPCPs) generates an enormous amount of chemicals, of which several groups warrant additional attention, including: (i) parabens, which are widely used as preservatives; (ii) bisphenols, which are used in the manufacture of plastics; (iii) UV ...

The Aryl Hydrocarbon Receptor (AhR), a ligand-activated transcription factor, orchestrates responses to numerous structurally diverse endogenous and exogenous ligands. In addition to binding various xenobiotics, AhR also recognizes endocrine disruptors, particularly those featuring chlorinated or br ...

We report on the design, synthesis, and biological evaluation of a series of nucleotide-binding oligomerization-domain-containing protein 2 (NOD2) desmuramylpeptide agonists with improved in vitro and in vivo adjuvant properties. We identified two promising compounds: 68, a potent nanomolar in vitro ...