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New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel
Nace Zidar, Tihomir Tomašić, Danijel Kikelj, Martina Durcik, Jan Tytgat, Marc Rogers, Alexander Haworth, Robert W. Kirby
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Oznake: napetostno odvisni natrijev kanal;Nav kanal;Nav1.3;zaviralci;arilsulfonamid;acilsulfonamid;Voltage-gated sodium channel;Nav channel;inhibitor;arylsulfonamide;acylsulfonamide;
Voltage-gated sodium channels (Navs) play an essential role in neurotransmission, and their dysfunction is often a cause of various neurological disorders. The Nav1.3 isoform is found in the CNS and upregulated after injury in the periphery, but its role in human physiology has not yet been fully el ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
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