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Št. zadetkov: 4
Načini upravljanja korupcije v sodobni družbi
Jure Gobec, Branko Lobnikar, Bojan Dobovšek
Diplomsko delo
Oznake: korupcija;družba;družbeni sistem;diplomske naloge;
Cilj diplomske naloge je analizirati usklajenost sistemskih dejavnikov (institucij, zakonodaje itd.) v Republiki Sloveniji s sosednjimi državami ter z mednarodnimi institucijami. Osredotočimo se predvsem na načine upravljanja korupcije v naši državi in njene elemente za upravljanje ter institucije, ...
Leto: 2014 Vir: Fakulteta za varnostne vede (UM FVV)
From tryptophan-based amides to tertiary amines
Anže Meden, Damijan Knez, Xavier Brazzolotto, Florian Nachon, Jose Dias, Jurij Svete, Jure Stojan, Uroš Grošelj, Stanislav Gobec
Izvirni znanstveni članek
Oznake: zaviralci holinesteraze;butirilholinesteraza;karbamat;psevdoireverzibilna inhibicija;cholinesterase inhibitors;Alzheimer's disease;butyrylcholinesterase;carbamate;pseudoirreversible inhibition;
Lead optimization of a series of tryptophan-based nanomolar butyrylcholinesterase (BChE) inhibitors led to tertiary amines as highly potent, achiral, sp (Chierrito et al., 2018) [3]-rich analogues with better synthetic accessibility and high selectivity over acetylcholinesterase (one to ten thousand ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec
Izvirni znanstveni članek
Oznake: butyrylcholinesterase;inhibitor;probe;fluorescence;
Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer's disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal structure of previously described highly potent, revers ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Stanislav Gobec, José Marco-Contelles
Izvirni znanstveni članek
Oznake: multifunkcionalni ligandi;kinolilnitroni;encimska kinetika;
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase –hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weig ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 4
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