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Št. zadetkov: 6
Genetske spremembe ter prostocelične in vezikularne miRNA kot biološki označevalci blage kognitivne motnje in Alzheimerjeve bolezni
David Vogrinc, Katja Goričar
Doktorska disertacija
Oznake: Alzheimerjeva bolezen;blaga kognitivna motnja;genetska variabilnost;miRNA;biološki označevalci;
Ozadje: Alzheimerjeva bolezen (AB) je progresivna nevrodegenerativna bolezen, ki prizadene občuten delež starajoče se populacije. Večinoma se prične z blago kognitivno motnjo (BKM), ki različno hitro napreduje do Alzheimerjeve demence (AD). Biološki označevali bi lahko omogočili boljši in zgodnejši ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Genetic Variability in Molecular pathways implicated in Alzheimer's disease
David Vogrinc, Katja Goričar, Vita Dolžan
Pregledni znanstveni članek
Oznake: Alzheimer's disease;genetic risk factors;pathogenesis;
Alzheimer's disease (AD) is a complex neurodegenerative disease, affecting a significant part of the population. The majority of AD cases occur in the elderly with a typical age of onset of the disease above 65 years. AD presents a major burden for the healthcare system and since population is rapid ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Systematic search for novel circulating biomarkers associated with extracellular vesicles in Alzheimerʹs disease
David Vogrinc, Katja Goričar, Tanja Kunej, Vita Dolžan
Izvirni znanstveni članek
Oznake: medicina;Alzheimerjeva bolezen;bioinformatika;biomarkerji;genetika;miRNA;zunajcelični vezikli;
miRNAs play an important role in neurodegenerative diseases. Many miRNA-target gene interactions (MTI) have been experimentally confirmed and associated with Alzheimer’s disease (AD). miRNAs may also be contained within extracellular vesicles (EVs), mediators of cellular communication and a potentia ...
Leto: 2021 Vir: Biotehniška fakulteta (UL BF)
Shared miRNA landscapes of COVID-19 and neurodegeneration confirm neuroinflammation as an important overlapping feature
Sara Redenšek, David Vogrinc, Katja Goričar, Vita Dolžan, Vita Dolžan
Izvirni znanstveni članek
Oznake: COVID-19;neurodegeneration;Alzheimer’s disease;
Introduction: Development and worsening of most common neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, have been associated with COVID-19 However, the mechanisms associated with neurological symptoms in COVID-19 patients and neurodegenerative seq ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Genetic polymorphisms in oxidative stress and inflammatory pathways as potential biomarkers in Alzheimer’s Disease and dementia
David Vogrinc, Milica Gregorič Kramberger, Andreja Emeršič, Saša Čučnik, Katja Goričar, Vita Dolžan, Vita Dolžan
Izvirni znanstveni članek
Oznake: Alzheimerjeva bolezen;oksidativni stres;vnetje;Alzheimer’s disease;oxidative stress;inflammation;
Oxidative stress and neuroinflammation are important processes involved in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Numerous risk factors, including genetic background, can affect the complex interplay between those mechanisms in the aging brain and can also affect typical AD ha ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Inaktivacija genskih skupin izbranih biološko aktivnih sekundarnih metabolitov v bakterijah vrste Streptomyces rapamycinicus
David Vogrinc, Hrvoje Petković, Hrvoje Petković, Marko Blažič, Marko Blažič, Mojca Narat, Darja Žgur-Bertok, Darja Žgur-Bertok
Magistrsko delo
Oznake: streptomicete;Streptomyces rapamycinicus;genetski inženiring;inaktivacija genov;sekundarni metaboliti;
Sekundarni metabolizem streptomicet je pogosto izredno kompleksen in raznovrsten. Njihovi genomi imajo zapis za biosintezo številnih biološko aktivnih učinkovin, med katerimi številne izkazujejo protibakterijsko delovanje. Napredek na področju identificiranja genskih gruč in njihove anotacije v geno ...
Leto: 2018 Vir: Biotehniška fakulteta (UL BF)
Št. zadetkov: 6
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