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Št. zadetkov: 2
Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
Maša Sinreih, Rebeka Jójárt, Zoltán Kele, Tomaž Büdefeld, Gábor Paragi, Erzsébet Mernyák, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: aldo-keto reduktaze;halogenirani derivati estrona;zaviranje;
Facile syntheses of 3-O-carbamoyl, -sulfamoyl, or -pivaloyl derivatives of 13[alpha]-oestrone and its 17-deoxy counterpart have been carried out. Microwave-induced, Ni-catalysed Suzuki-Miyaura couplings of the newly synthesised phenol esters with phenylboronic acid afforded 3-deoxy-3-phenyl-13a-oest ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Directed C–H activation of 13α-estrone
Erzsébet Mernyák, Marija Gjorgoska, Maša Sinreih, Aljaž Kotnik, Zala Zanoškar, Ajda Godec, Marko Jukič, Urban Bren, Rebeka Ignácz, Kornél Szőri, Zoltán Kele, Attila Hunyadi, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: encimi;inhibitorji;lokalni steroidni hormoni;local steroid hormone;AKR1C enzymes;inhibitors;
The aldo-keto reductase isoenzymes AKR1C1–3 regulate local steroid hormone availability through the interconversion of active and inactive ligands, thereby modulating prereceptor signaling. This regulatory mechanism has been implicated in the progression of hormone-dependent malignancies, highlighti ...
Leto: 2026 Vir: Digitalna knjižnica Univerze v Mariboru (DKUM)
Št. zadetkov: 2
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