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Št. zadetkov: 2
Varicella-zoster virus recapitulates its immune evasive behaviour in matured hiPSC-derived neurospheroids
Jonas Govaerts, Elise Van Breedam, Helena Motaln, Boris Rogelj, Peter Ponsaerts
Izvirni znanstveni članek
Oznake: interferon signalling;neurospheroids;antigen presentation;stress granules;structural integrity;
Varicella-zoster virus (VZV) encephalitis and meningitis are potential central nervous system (CNS) complications following primary VZV infection or reactivation. With Type-I interferon (IFN) signalling being an important first line cellular defence mechanism against VZV infection by the peripheral ...
Leto: 2024 Vir: Institut Jožef Stefan (IJS)
Transcriptomic and proteomic profiling of bi-partite and tri-partite murine iPSC-derived neurospheroids under steady-state and inflammatory condition
Julia Di Stefano, Laura Garcia-Pupo, Helena Motaln, Boris Rogelj, Peter Ponsaerts
Izvirni znanstveni članek
Oznake: vnetni odziv;proteomika;murine induced-pluripotent cells;neurospheroids;inflammatory response;stress granules;transcriptomics;proteomics;
Induced-pluripotent stem cell (iPSC)-derived neurospheroid (NSPH) models are an emerging in vitro toolkit to study the influence of inflammatory triggers on neurodegeneration and repair in a 3D neural environment. In contrast to their human counterpart, the absence of murine iPSC-derived NSPHs for p ...
Leto: 2024 Vir: Institut Jožef Stefan (IJS)
Št. zadetkov: 2
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