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Št. zadetkov: 2
Development of the fish invitrome for animal-free environmental risk assessment of chemicals
Marion Revel, Ksenia J Groh, Jessica Bertoli, Mihai-Ovidiu Degeratu, Melanie Fischer, Stephan Fischer, Jarno Hoekman, Barbara Jozef, Roman Li, Anže Županič
Izvirni znanstveni članek
Oznake: sistemska toksikologija;alternative eksperimentom na živalih;mavrična postrv;ekotoksikologija;new approach methodologies (NAMs);rainbow trout cell lines;toxicity testing;socio-technical approach;co-design with stakeholders;
Given the need to reduce animal testing for environmental risk assessment, we aim to develop a fish invitrome, an alternative fish modular framework capable of predicting chemical toxicity in fish without the use of animals. The central module of the framework is the validated RTgill-W1 cell line as ...
Leto: 2025 Vir: Nacionalni inštitut za biologijo (NIB)
Zirconia-toughened alumina ceramic wear particles do not elicit inflammatory responses in human macrophages
Alessandro Alan Porporati, Yvonne Mödinger, Sarah Fischer, Sara Polajžer, Melanie Mettang, Ulrike Deisinger, Matejka Podlogar, Rihard Trebše, Nika Lovšin
Izvirni znanstveni članek
Oznake: orthopaedic implant;alumina;zirconia-toughened alumina (ZTA);nanoparticles;macrophages;cell viability;inflammation;cytokine secretion;
Ten percent of patients undergoing total hip arthroplasty (THA) require revision surgery. One of the reasons for THA are wear particles released from the implants that can activate the immune defense and cause osteolysis and failure of the joint implant. The discrepancies between reports on toxicity ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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