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Synthesis, antimycobacterial activity, and computational insight of novel 1,4-benzoxazin-2-one derivatives as promising candidates against multidrug-resistant mycobacterium tuberculosis
Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukič, Daniele Zampieri
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Oznake: antimycobacterial;benzoxazinones;cytotoxicities;dockings;menaquinone-B;minimum inhibitory concentrations;
In the search for new antitubercular agents, a series of 1,4-benzoxazinone-based compounds is designed, synthesized, and evaluated. These molecules show potent antimycobacterial activity, with a minimum inhibitory concentration between 2 and 8 μg mL−1. This interesting profile includes activity agai ...
Leto: 2025 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UM FKKT)
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