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Št. zadetkov: 7
Načini upravljanja korupcije v sodobni družbi
Jure Gobec, Branko Lobnikar, Bojan Dobovšek
Diplomsko delo
Oznake: korupcija;družba;družbeni sistem;diplomske naloge;
Cilj diplomske naloge je analizirati usklajenost sistemskih dejavnikov (institucij, zakonodaje itd.) v Republiki Sloveniji s sosednjimi državami ter z mednarodnimi institucijami. Osredotočimo se predvsem na načine upravljanja korupcije v naši državi in njene elemente za upravljanje ter institucije, ...
Leto: 2014 Vir: Fakulteta za varnostne vede (UM FVV)
Expanding the reactive chemistry toolbox – warhead screening for covalent butyrylcholinesterase inhibitors
Anže Meden, Xavier Brazzolotto, Jose Dias, Jure Stojan, Damijan Knez, Stanislav Gobec
Izvirni znanstveni članek
Oznake: zaviralci holinesteraze;bojna glava;ireverzibilna inhibicija;butirilholinesteraza;karbamat;cholinesterase inhibitors;warhead;irreversible inhibition;butyrylcholinesterase;carbamate;
Many covalent inhibitors of butyryl- and acetylcholinesterase, typically featuring electrophilic carbamoyl, phosphonyl, and sulfonyl groups, were reported in the literature. In this study, we screened these and several other electrophilic moieties for covalent cholinesterase inhibition. The electrop ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
From tryptophan-based amides to tertiary amines
Anže Meden, Damijan Knez, Xavier Brazzolotto, Florian Nachon, Jose Dias, Jurij Svete, Jure Stojan, Uroš Grošelj, Stanislav Gobec
Izvirni znanstveni članek
Oznake: zaviralci holinesteraze;butirilholinesteraza;karbamat;psevdoireverzibilna inhibicija;cholinesterase inhibitors;Alzheimer's disease;butyrylcholinesterase;carbamate;pseudoirreversible inhibition;
Lead optimization of a series of tryptophan-based nanomolar butyrylcholinesterase (BChE) inhibitors led to tertiary amines as highly potent, achiral, sp (Chierrito et al., 2018) [3]-rich analogues with better synthetic accessibility and high selectivity over acetylcholinesterase (one to ten thousand ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec
Izvirni znanstveni članek
Oznake: butyrylcholinesterase;inhibitor;probe;fluorescence;
Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer's disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal structure of previously described highly potent, revers ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Stanislav Gobec, José Marco-Contelles
Izvirni znanstveni članek
Oznake: multifunkcionalni ligandi;kinolilnitroni;encimska kinetika;
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase –hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weig ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Chiral switch of a butyrylcholinesterase inhibitor for the treatment of Alzheimer's disease
Urban Košak, Damijan Knez, Svit Ferjančič Benetik, Peter Mastnak-Sokolov, Anja Pišlar, Selena Horvat, Jure Stojan, Bingbing Lv, Weiting Zhang, Yuanyuan Wang, Stanislav Gobec
Izvirni znanstveni članek
Oznake: chiral switch;resolution of enantiomers;Alzheimer's disease;butyrylcholinesterase;enzyme inhibitors;
Butyrylcholinesterase (BChE) is a viable drug target to alleviate the symptoms of Alzheimer's disease (AD). We recently developed and biologically evaluated racemic N-benzylpiperidine-based naphthalene-2-sulfonamide 2, a nanomolar BChE inhibitor with procognitive effects. To optimize it, we performe ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Lead optimization of a butyrylcholinesterase inhibitor for the treatment of Alzheimer’s disease
Urban Košak, Nika Strašek, Damijan Knez, Simon Žakelj, Jurij Trontelj, Anja Hafner, Selena Horvat, Aljoša Bolje, Neža Žnidaršič, Neža Grgurevič, Tanja Švara, Jakob Kljun, Jure Stojan, Stanislav Gobec
Izvirni znanstveni članek
Oznake: centralni živčni sistem;odkrivanje zdravil;inhibitorji;presejalni testi;sulfoni;central nervous system;drug discovery;inhibitors;screening assays;sulfones;
Butyrylcholinesterase (BChE) is a promising drug target for alleviating the symptoms of canine cognitive dysfunction (CCD) and Alzheimer’s disease (AD). We have recently developed lead compound 2, a racemic, nanomolar BChE inhibitor with procognitive effects in mice with scopolamine-induced AD-like ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 7
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