Št. zadetkov: 25
Izvirni znanstveni članek
Oznake:
microRNA;screening;vasculitis;
Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) comprises autoimmune disease entities that cause target organ damage due to relapsing-remitting small vessel necrotizing vasculitis, and which affects various vascular beds. The pathogenesis of AAV is incompletely understood, whic ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
ANCA;vasculitis;glomerulonephritis;microRNA;biomarker;BVAS;epigenetics;follow-up;
Introduction: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is an autoimmune necrotizing small vessel vasculitis, frequently resulting in severe renal manifestations such as rapidly progressive glomerulonephritis (AAV-GN). Monitoring disease activity and determining ongoing renal ...
Leto:
2025
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Izvirni znanstveni članek
Oznake:
bacterial cystitis;expression analysis;inflammation;interstitial cystitis;microRNA;pathway analysis;reporter assay-validated targets;urinary bladde;
Introduction: Interstitial cystitis (IC) is an aseptic chronic bladder inflammation of unknown etiology and poorly understood pathophysiology with symptoms resembling bacterial cystitis (BC). There is limited data about the contribution of regulatory microRNAs (miRNAs) in IC. The study aimed to iden ...
Leto:
2026
Vir:
Medicinska fakulteta (UL MF)
Magistrsko delo
Oznake:
SLITRK6;kancerogeneza;različice;glikozilacija;
Protein SLITRK6 (SLIT in NTRK podobni protein 6) je monomeren transmembranski
protein iz družine SLITRK, ki je povezan z delovanjem živčnega sistema. Za proteine
družine SLITRK so značilne z levcinom bogate regije. SLITRK6 je eden izmed ključnih
dejavnikov pri sinaptogenezi in je posledično selek ...
Leto:
2026
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Doktorska disertacija
Oznake:
ANCA;vaskulitis;glomerulonefritis;mikroRNA;označevalec;epigenetika;
V doktorski disertaciji smo raziskovali patogenetski, diagnostični in napovedni pomen regulatornih kratkih nekodirajočih molekul mikro RNA (miRNA) pri vaskulitisu, povezanim s prisotnostjo protinevtrofilnih protiteles (angl. ANCA-associated vasculitis, AAV).
V multifaktorski patogenezi tkivne okvar ...
Leto:
2025
Vir:
Medicinska fakulteta (UL MF)
Doktorska disertacija
Oznake:
Epitelijsko-mezenhimski prehod;ledvični karcinom;svetlocelični karcinom ledvičnih celic;sarkomatoidni karcinom ledvic;mikroRNA;mRNA;dolge nekodirajoče RNA;transkripcijski faktorji;venska invazija;
Epitelijsko-mezenhimski prehod (EMP) je večstopenjski biološki proces, vključen v številne fiziološke procese, pomembno vlogo pa ima tudi pri napredovanju in zasevanju različnih tumorjev. EMP se sproži prek signalov iz tumorskega mikrookolja, kar prek sprememb v izražanju ključnih genov in posttrans ...
Leto:
2026
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
colorectal adenoma;colorectal carcinoma;metastases;intra-tumour heterogeneity;epithelial-mesenchymal transition;miR-200 family;target genes;
MicroRNAs of the miR-200 family have been shown experimentally to regulate epithelialmesenchymal transition (EMT). Although EMT is the postulated mechanism of development and progression of colorectal cancer (CRC), there are still limited and controversial data on expression of miR-200 family and th ...
Leto:
2019
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
extracellular matrix;colorectal carcinoma;colorectal polyps;
Colorectal carcinoma usually evolves gradually, forming a spectrum of lesions, due to accumulation of genetic mutations and epigenetic alterations. Many early lesions are detected since the introduction of screening programs. The greatest challenge is to distinguish between adenomas with epithelial ...
Leto:
2020
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
colorectal cancer;differentially expressed genes;cancer stem cells;
Significant progress has been made in the last decade in our understanding of the pathogenetic mechanisms of colorectal cancer (CRC). Cancer stem cells (CSC) have gained much attention and are now believed to play a crucial role in the pathogenesis of various cancers, including CRC. In the current s ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
web aplication;RNA expression;colorectal cancer;gene expression;knowledge base;cancer genome atlas;miRNA;mRNA;gene correlation;target genes;
"miRNA colorectal cancer" (https://mirna-coadread.omics.si/) is a freely available web application for studying microRNA and mRNA expression and their correlation in colorectal cancer. To the best of our knowledge, %miRNA colorectal cancer% has the largest knowledge base of miRNA-target gene express ...
Leto:
2019
Vir:
Medicinska fakulteta (UL MF)