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Št. zadetkov: 7
Izražanje miR-195-5p in miR-204-5p ter njunih potencialnih tarčnih genov v kostnem tkivu bolnikov z osteoporozo in osteoartrozo
Barbara Čugalj Kern, Barbara Ostanek, Simona Mencej Bedrač
Magistrsko delo
Oznake: osteoartroza;miR-195-5p;miR-204-5p;osteonektin;kostni morfogeni protein;alkalna fosfataza;elongaza maščobnih kislin 6;
Izražanje miR-195-5p in miR-204-5p ter njunih potencialnih tarčnih genov v kostnem tkivu bolnikov z osteoporozo in osteoartrozo
Leto: 2016 Vir: Fakulteta za farmacijo (UL FFA)
Epigenetic enzymes influenced by oxidative stress and hypoxia mimetic in osteoblasts are differentially expressed in patients with osteoporosis and osteoarthritis
Peter Vrtačnik, Janja Zupan, Vid Mlakar, Tilen Kranjc, Janja Marc, Barbara Čugalj Kern, Barbara Ostanek
Izvirni znanstveni članek
Oznake: oksidativni stres;homeostaza;Gensko izražanje;
Epigenetic mechanisms including posttranslational histone modifications and DNA methylation are emerging as important determinants of bone homeostasis. With our case-control study we aimed to identify which chromatin-modifying enzymes could be involved in the pathology of postmenopausal osteoporosis ...
Leto: 2018 Vir: Fakulteta za farmacijo (UL FFA)
Exploring early DNA methylation alterations in type 1 diabetes
Barbara Čugalj Kern, Jernej Kovač, Robert Šket, Barbara Jenko, Julia Galhardo, Tadej Battelino, Nataša Bratina, Klemen Dovč
Izvirni znanstveni članek
Oznake: type 1 diabetes;glycemic control;DNA methylation;diabetes-related complications;long-read sequencing;
Background: Prolonged hyperglycemia causes diabetes-related micro- and macrovascular complications, which combined represent a significant burden for individuals living with diabetes. The growing scope of evidence indicates that hyperglycemia affects the development of vascular complications through ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Prevalence, genetic variants, and clinical implications of hypocholesterolemia in children
Urh Grošelj, Jan Kafol, Neža Molk, Katarina Sedej, Matej Mlinarič, Jaka Šikonja, Urša Šuštar, Barbara Čugalj Kern, Jernej Kovač, Tadej Battelino, Maruša Debeljak, Maruša Debeljak
Izvirni znanstveni članek
Oznake: APOB;children;hypocholesterolemia;next-generation sequencing;prevalence;
Background and aims: In contrast to extensively studied hypercholesterolemia, knowledge of hypocholesterolemia is limited. This study aims to assess the prevalence, clinical characteristics, and genetics of children and adolescents with hypocholesterolemia. Methods: This national prospective cross-s ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Sex differences in cholesterol levels among prepubertal children
Jan Kafol, Mia Becker, Barbara Čugalj Kern, Jaka Šikonja, Matej Mlinarič, Katarina Sedej, Matej Kafol, Ana Drole Torkar, Jernej Kovač, Tadej Battelino, Urh Grošelj
Izvirni znanstveni članek
Oznake: sex differences;prepubertal children;total cholesterol;low-density lipoprotein cholesterol;familial hypercholesterolemia;
Background and aims: Sex differences in cholesterol levels are well documented in adults and adolescents, but limited data exist for prepubertal children. This study aimed to evaluate innate sex differences in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels among prepub ...
Leto: 2025 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Integrating genetic insights, technological advancements, screening, and personalized pharmacological interventions in childhood obesity
Robert Šket, Robert Šket, Barbara Slapnik, Primož Kotnik, Klementina Črepinšek, Barbara Čugalj Kern, Tine Tesovnik, Barbara Jenko, Blaž Vrhovšek, Žiga Iztok Remec, Maruša Debeljak, Tadej Battelino, Jernej Kovač
Pregledni znanstveni članek
Oznake: hemophilia;wearable;Florio HAEMO;adherence;patient satisfaction;
Childhood obesity is a significant global health challenge with rising prevalence over the past 50 years, affecting both immediate and long-term health outcomes. The increase in prevalence from 0.7% to 5.6% in girls and 0.9% to 7.8% in boys highlights the urgency of addressing this epidemic. By 2025 ...
Leto: 2025 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Universal screening for familial hypercholesterolemia in preschool children and their families in Slovenia (FH-FAMILIES)
Mia Becker, Bernarda Vogrin, Jan Kafol, Barbara Čugalj Kern, Urh Grošelj, Jernej Završnik, Matej Mlinarič, Ana Drole Torkar, Jaka Šikonja, Jernej Kovač, Tadej Battelino, Zlatko Fras, Matija Cevc, Borut Jug, Barbara Krevel, Tevž Gorjanc, Klara Zabkar, Aljaz Jamnik, Maruša Debeljak, Ana Grom, Tamara Grgic, Miha Švarc, Maja Filipič, Mineja Leban, Marija Kjoseva Bakarova, Mateja Šnajder, Alenka Koren, Mojca Mir Toplak, Mojca Ivankovič Kacjan, Mario Kulaš, Benjamina Trtnik, Saša Korez, Nina Hebar, Bernarda Vogel, Vesna Amon Prodnik, Lidija Pretnar, Janja Schweiger Nemanič
Izvirni znanstveni članek
Oznake: hypercholesterolemia;universal screening;preschoolers;total cholesterol;genetic testing;
Familial hypercholesterolemia (FH) is the most common metabolic disease, with prevalence estimated between 1:250 and 1:300. The affected individuals have a significantly higher risk for developing atherosclerosis and cardiovascular disease (CVD) compared to non-affected individuals. Early CVD can be ...
Leto: 2025 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Št. zadetkov: 7
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