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Št. zadetkov: 2
Targeting steroid-metabolizing enzymes with 15β-substituted estrone analogues
Vivien Resch, Marija Gjorgoska, Eva Hafner, Ildikó Bacsa, Benjamin Kovács, Tomaž Büdefeld, Attila Hunyadi, Ildikó Huliák, Mónika Kiricsi, Gábor Paragi, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: 17β-HSD1 enzyme;AKR1C1–3 enzymes;antiproliferative;chemoresistance;fluorescent labeling;inhibitor;
Background/objectives: Aldo-keto reductase isoforms AKR1C1-3 and 17β-hydroxysteroid dehydrogenase 1 and 2 (17β-HSD1 and 17β-HSD2) are key enzymes in steroid metabolism and validated targets in hormone-dependent cancers. Methods: In this study, Δ15- and 15β-substituted estrone derivatives were evalua ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Directed C–H activation of 13α-estrone
Erzsébet Mernyák, Erzsébet Mernyák, Marija Gjorgoska, Maša Sinreih, Aljaž Kotnik, Zala Zanoškar, Ajda Godec, Marko Jukič, Urban Bren, Rebeka Ignácz, Kornél Szőri, Zoltán Kele, Attila Hunyadi, Tea Lanišnik-Rižner, Tea Lanišnik-Rižner
Izvirni znanstveni članek
Oznake: encimi;inhibitorji;lokalni steroidni hormoni;local steroid hormone;AKR1C enzymes;inhibitors;
The aldo-keto reductase isoenzymes AKR1C1–3 regulate local steroid hormone availability through the interconversion of active and inactive ligands, thereby modulating prereceptor signaling. This regulatory mechanism has been implicated in the progression of hormone-dependent malignancies, highlighti ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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