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Št. zadetkov: 5
Sinteza in vrednotenje sond na osnovi kumarinskega in fenoksazinskega skeleta za mikroskopijo z vzbujenim praznjenjem emisije
Alen Gabrič, Janez Mravljak, Stane Pajk
Magistrsko delo
Oznake: Mikroskopija z vzbujenim praznjenjem emisije / membranske sonde / dvojni naboj / kumarin / fenoksazin;
Mikroskopija z vzbujenim praznjenjem emisije (STED) je super-ločljivostna tehnika, ki omogoča preseganje difrakcijske limite, zaradi česar lahko natančneje preučujemo strukture, ki jih s klasičnimi mikroskopi ne moremo. Zaradi velike uporabnosti mikroskopov STED v naravoslovni znanosti, so tudi potr ...
Leto: 2019 Vir: Fakulteta za farmacijo (UL FFA)
Oxidation of drugs during drug product development
Alen Gabrič, Žiga Hodnik, Stane Pajk
Pregledni znanstveni članek
Oznake: nečistoče;novi oksidativni stresorji;testiranje oksidativnega stresa;peroksidi;oxidation;peroxides;impurities;new oxidative stressors;oxidative stress testing;
Oxidation is the second most common degradation pathway for pharmaceuticals, after hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex and produces a wider range of degradation products; oxidation is thus harder to control. The propensity of a drug towards oxida ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Impact of peroxide content in excipients and antioxidants on famotidine oxidative stability
Alen Gabrič, Žiga Hodnik, Janez Ilaš, Stane Pajk
Izvirni znanstveni članek
Oznake: peroksidi;vodikov peroksid;famotidin;kemične spojine;programska oprema Zeneth;peroxides;hydrogen peroxide;famotidine;chemical compounds;Zeneth software;
Famotidine, a widely used H2-receptor antagonist, exhibits sensitivity to oxidative degradation, particularly in the presence of excipients containing peroxide impurities. This study explores the oxidative stability of famotidine under various storage conditions, with a specific focus on excipients ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
One-pot HPLC method for simultaneous quantification of hydrogen peroxide and organic peroxides
Alen Gabrič, Žiga Hodnik, Janez Ilaš, Stane Pajk
Izvirni znanstveni članek
Oznake: kvantifikacija peroksida;vodikov peroksid;organski peroksidi;borova kislina;tekočinska kromatografija;HPLC;peroxide quantification;hydrogen peroxide;organic peroxides;borinic acid;liquid chromatography;
Hydrogen peroxide and organic peroxides are widely used in the pharmaceutical and food industries as disinfectants, preservatives, and bleaching agents. They can also form as by-products during polymerization, drying, or degradation processes, potentially compromising product quality. While current ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Amphiphilic coumarin-based probes for live-cell STED nanoscopy of plasma membrane
Hana Majaron, Boštjan Kokot, Anja Hafner, Hana Esih, Alen Gabrič, Dunja Urbančič, Rojbin El, Iztok Urbančič, Stane Pajk
Izvirni znanstveni članek
Oznake: fizika;membrane;fluorescenca;
Plasma membranes are vital biological structures, serving as protective barriers and participating in various cellular processes. In the field of super-resolution optical microscopy, stimulated emission depletion (STED) nanoscopy has emerged as a powerful method for investigating plasma membrane-rel ...
Leto: 2024 Vir: Institut Jožef Stefan (IJS)
Št. zadetkov: 5
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