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Št. zadetkov: 2
ǂA ǂnew method for testing the anti-permeability strength of clay failure under a high water pressure
Fu-wei Jiang, Ming-tang Lei, Xiao-zhen Jiang
Izvirni znanstveni članek
Oznake: clay failure;seepage deformation;anti-permeability strength;high water pressure;
It is difficult to judge the failure of clay seepage under a high water pressure.This paper presents a new method to assess clay failure based on the anti-permeability strength, which is the critical water pressure to destroy the clay. An experiment is designed to test the value that avoids the prob ...
Leto: 2015 Vir: Fakulteta za gradbeništvo, prometno inženirstvo in arhitekturo (UM FGPA)
Discovery of SMD-6346
Lingying Leng, Liyue Huang, Wenbin Tu, Wei Jiang, Rohan Kalyan Rej, Srinivasa Rao Allu, Yu Wang, Mi Wang, Jelena Tošović, Meilin Wang
Izvirni znanstveni članek
Oznake: PROTAC;targeted protein degradation;SMARCA2;SMARCA4;cancer;oral bioavailability;
Selective targeting SMARCA2 by degradation represents a promising new therapeutic strategy for human cancers harboring deficient SMARCA4. Herein we report the discovery of highly potent, selective and oral available SMARCA2 PROTAC degraders, as exemplified by SMD-6346. SMD-6346 achieves DC50 = 3.3 n ...
Leto: 2026 Vir: Fakulteta za matematiko, naravoslovje in informacijske tehnologije Koper (UP FAMNIT)
Št. zadetkov: 2
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