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Optimization of 6-(trifluoromethyl)pyrimidine derivatives as TLR8 antagonists
Nika Strašek, Valerij Talagayev, Troy Matziol, Ana Dolšak, Izidor Sosič, Günther Weindl, Gerhard Wolber, Matej Sova
Izvirni znanstveni članek
Oznake: Toll-like receptors;TLR8 antagonists;autoimmune disorders;immunomodulation;pyrimidines;
Toll-like receptors (TLRs) are essential for the innate immune system as they recognize pathogen-associated molecular patterns and trigger immune responses. Overactivation of TLR8 by endogenous nucleic acids is associated with the development of autoimmune diseases and promotes inflammatory response ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
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