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Št. zadetkov: 5
Zaviranje katepsina X z endogenimi zaviralci cisteinskih peptidaz
Timotej Žvanut, Urša Pečar Fonović
Magistrsko delo
Oznake: katepsin X;endogeni zaviralci;encimska kinetika;patogeneza raka;aktivnosti katepsina X;
Zaviranje katepsina X z endogenimi zaviralci cisteinskih peptidaz
Leto: 2017 Vir: Fakulteta za farmacijo (UL FFA)
Exploiting hyphenated liquid chromatography for in-process control of adeno-associated virus 8 manufacturing
Timotej Žvanut, Mitja Martelanc, Aleš Štrancar
Doktorska disertacija
Oznake: adeno-associated virus serotype 8;empty-full-partially filled capsid LC-based hyphenated separation;1D and 2D;analytical platforms;process monitoring;anion-exchange chromatography;separation mechanisms;preliminary stability;scalability;dissertations;
Adeno-associated virus (AAV) manufacturing is challenged by pronounced capsid heterogeneity, process variability, and limitations of current analytical methods. AAV preparations contain diverse capsid populations that affect potency, safety, and batch consistency, while existing analytical approache ...
Leto: 2026 Vir: Repozitorij Univerze v Novi Gorici (RUNG)
Mechanistic insights into AAV capsid–stationary phase interactions governing native stability and chromatographic separation using AAV8 as a model system
Timotej Žvanut, Mitja Martelanc, Aleš Štrancar, Andreja Gramc-Livk
Izvirni znanstveni članek
Oznake: adeno-associated virus;empty/partially filled/full;separation efficiency;capsid stability;weak anion exchanger;interactions;in-line buffer exchange;
Background/Objectives: Adeno-associated viruses (AAVs) are widely used gene therapy vectors; yet their physicochemical stability and chromatographic behavior are highly sensitive to the solution conditions they are in. Effective separation of full (F), empty (E), and partially filled (P) capsids—mos ...
Leto: 2026 Vir: Univerza v Novi Gorici (UNG)
ǂA ǂtwo-dimensional hyphenated ion-exchange chromatographic platform for simultaneous assessment of AAV8 capsids and impurity fingerprinting in upstream processes
Timotej Žvanut, Tjaša Kašček, Lara Vogrinčič, Petra Dekleva, Sandra Hasić, Anže Martinčič Celjar, Ivana Petrović Koshmak, Blaž Goričar, Mitja Martelanc, Aleš Štrancar, Andreja Gramc-Livk
Izvirni znanstveni članek
Oznake: complex samples;upstream process monitoring;two-dimensional hyphenated liquid chromatography;Adeno-associated virus;full capsid content;
Reliable monitoring of full (F) versus empty (E) adeno-associated virus (AAV) capsids, along with impurity fingerprinting, is essential for optimising upstream processes (USPs). Conventional analytical workflows for USP monitoring, including PCR-ELISA and one-dimensional (1D) liquid chromatography ( ...
Leto: 2026 Vir: Univerza v Novi Gorici (UNG)
Uvedba e-dokumentacije pacienta v zdravstveni negi
Timotej Kos, Boštjan Žvanut
Diplomsko delo
Oznake: informacijsko-komunikacijska tehnologija;elektronska zdravstvena dokumentacija;digitalizacija;medicinske sestre;zdravstvena nega;
Leto: 2022 Vir: Fakulteta za vede o zdravju (UP FVZ)
Št. zadetkov: 5
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