Št. zadetkov: 48
Pregledni znanstveni članek
Oznake:
rak jajčnikov;estrogeni;imunosupresivno mikrookolje;ovarian cancer;estrogens;immunosuppressive microenvironment;
Ovarian cancer is a heterogeneous disease affecting the aging ovary, in concert with a complex network of cells and signals, together representing the ovarian tumor microenvironment. As in the "Schrödinger's cat" thought experiment, the context-dependent constituents of the-by the time of diagnosis- ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
endocrinology;endometrial cancer;androgen hormones;
Endometrial cancer (EC) is a gynecological pathology that affects the uterine inner lining. In recent years, genomic studies revealed continually evolving muta- tional landscapes of endometrial tumors that hold great potential for tailoring therapeutic strategies. This review aims to broaden our kno ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
nosečnice;intrakrinologija;rak endometrija;rak prostate;intracrinology;endometrial cancer;prostate cancer;
Local formation and action of estrogens have crucial roles in hormone dependent cancers and benign diseases like endometriosis. Drugs that are currently used for the treatment of these diseases act at the receptor (i.e., they interfere with the hormone receptor) and at the pre-receptor levels, targe ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
androgen hormones;endometriosis sub-phenotypes;ovarian neoplasms;two-sample Mendelian randomization;
Endometriosis is a complex gynecological pathology with a broad spectrum of symptoms, affecting around 10% of reproductive-aged women. Ovarian cancer (OC) is a heterogeneous disease for which we lack effective diagnostic and therapeutic strategies. The etiology and pathogenesis of both diseases rema ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
liquid chromatography-tandem mass spectrometry;androgens;progestogens;mineralocorticoids;glucocorticoids;11-oxygenenated steroids;
Mass spectrometric-based steroidomics is a valuable analytical approach that gives a comprehensive understanding of the interlinked steroid biosynthetic pathways. Here, we describe a rapid and versatile liquid chromatography-tandem mass spectrometry (LC-MS/MS) method designed to accurately quantify ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
androgens;estrogens;intracrinology;sulfatase;sulfotransferase;
Sulfatase (STS) and sulfotransferases (SULT) have important role in the biosynthesis and action of steroid hormones. STS catalyzes the hydrolysis of estrone-sulfate (E1-S) and dehydroepiandrosterone-sulfate (DHEA-S), while sulfotransferases catalyze the reverse reaction and require 3-phosphoadenosin ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
endometrial cancer;11-oxyandrogens;intracrinology;androgen receptor;LC-MS/MS profiling;
Background: Endometrial cancer (EC) is a prevalent gynecological malignancy globally, with a rising incidence trend. While classic androgens have been implicated with EC risk, the role of their 11-oxygenated metabolites is poorly understood. Here, we studied 11-oxyandrogen formation from steroid pre ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
endometrial cancer;Cimicifuga racemosa;ovarian cancer;
In postmenopausal women, estrogen levels exclusively depend on local formation from the steroid precursors dehydroepiandrosterone sulfate and estrone sulfate (E1-S). Reduced estrogen levels are associated with menopausal symptoms. To mitigate these symptoms, more women nowadays choose medicine of na ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
cartilage oligomeric matrix protein;transforming growth factor-b-induced protein ig-h3;cancer antigen 125;blood biomarkers;endometriosis;non-invasive diagnosis;diagnostic algorithm;receiver operating characteristic curve;sensitivity;specificity;
STUDY QUESTION: Can cartilage oligomeric matrix protein (COMP) and transforming growth factor-b-induced protein ig-h3 (TGFBI) alone or in combination with cancer antigen 125 (CA-125) be considered as potential blood biomarkers of endometriosis? SUMMARY ANSWER: The results of this study indicate that ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
high-grade serous ovarian cancer;estrogen metabolisem;prognostic biomarkers;therapeutic targets;transcriptomic analysis;
The high mortality rate due to chemoresistance in patients with high-grade ovarian cancer (HGSOC) emphasizes the urgent need to determine optimal treatment strategies for advanced and recurrent cases. Our study investigates the interplay between estrogens and chemoresistance in HGSOC and shows clear ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)