Št. zadetkov: 13
Diplomsko delo
Oznake:
celična linija Hepg2;biosenzorski sistem;fluorescenčni protein DsRed;promotor p21;genotoksičnost;test Alamar Blue;izražanje poročevalskega proteina;
Ovrednotenje in optimizacija uporabe celičnega biosenzorskega sistema humanih jetrnih celic HepG2p21 DsRed za detekcijo genotoksičnih snovi
Leto:
2011
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Izvirni znanstveni članek
Oznake:
Parkinsonova bolezen;motorični zapleti;vizualne halucinacije;Parkinson’s disease;motor complications;visual hallucinations;
The serotonergic system is important in Parkinson’s disease (PD) pathogenesis as it can take over dopamine production after a large portion of dopaminergic neurons is lost through neurodegeneration. The aim of this study was to evaluate the effect of genetic variability of serotonergic genes on the ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
nevrologija;Parkinsonova bolezen;receptor vitamina D;nevroznanost;
Vitamin D is a lipid-soluble molecule and an important transcriptional regulator in many tissues and organs, including the brain. Its role has been demonstrated also in Parkinson’s disease (PD) pathogenesis. Vitamin D receptor (VDR) is responsible for the initiation of vitamin D signaling cascade. T ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
diabetes mellitus type 2;oxidative pathway;genetic polymorphism;microvascular complications;macrovascular complications;personalized medicine;
To investigate the association of KEAP1 rs1048290, rs9676881 and NFE2L2 rs6706649, rs6721961, rs35652124 polymorphisms with glycemic control and development of late complications in patients with type 2 diabetes mellitus (T2DM), a total of 316 T2DM patients were included in the retrospective genetic ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
glaucoma;inflammation;oxidative stress;
Oxidative stress and neuroinflammation are involved in the pathogenesis and progression of glaucoma. Our aim was to evaluate the impact of selected single-nucleotide polymorphisms in inflammation and oxidative stress genes on the risk of glaucoma, the patients' clinical characteristics and the glauc ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Objavljeni znanstveni prispevek na konferenci
Oznake:
antiangiogenic;integrins;gene electrotransfer;human endothelial cells;murine melanoma cells;plasmid AMEP;
The data on the biological responsiveness of melanoma and endothelial cells that are targeted by Antiangiogenic MEtargidin Peptide (AMEP) are limited; therefore, the antiproliferative, antimetastatic and antiangiogenic effects of AMEP were investigated in murine melanoma and human endothelial cells ...
Leto:
2013
Vir:
Fakulteta za vede o zdravju (UP FVZ)
Izvirni znanstveni članek
Oznake:
polymorphism;type 2 diabetes;treatment response;
We investigated the impact of genetic polymorphisms in the GLP1R and SLC5A2 genes on the response to treatment with glucagon-like peptide-1 receptor (GLP-1R) agonists and sodium-glucose co-transporter-2 (SLGT2) inhibitors in patients with type 2 diabetes mellitus (T2DM) in everyday clinical practice ...
Leto:
2025
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Izvirni znanstveni članek
Oznake:
glaucoma;latanoprost;matrix metalloproteinases;selective laser trabeculoplasty;single nucleotide polymorphisms;
In open-angle glaucoma, the increase in intraocular pressure (IOP) is caused by an increased resistance to aqueous humour outflow in the trabecular meshwork. Since genetic variability of matrix metalloproteinase (MMP) genes may influence extracellular matrix remodelling, we investigated their associ ...
Leto:
2024
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Izvirni znanstveni članek
Oznake:
Drug therapy;Electroporation;elektrokemoterapija;Gene transfer;Interleukin-12;Neoplasms, experimental;rak (medicina);Therapy cisplatin;Treatment out;zdravljenje
Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity
Leto:
2012
Vir:
Onkološki inštitut Ljubljana (OI)
Izvirni znanstveni članek
Oznake:
COVID-19;dexamethasone;glucocorticoid pathway;methylprednisolone;polymorphism;treatment outcome;
Introduction: Corticosteroids are widely used for the treatment of coronavirus disease (COVID)-19. Genetic polymorphisms of the glucocorticoid receptor, metabolizing enzymes, or transporters may affect treatment response to dexamethasone. This study aimed to evaluate the association of the glucocort ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)