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Št. zadetkov: 3
Izvirni znanstveni članek
Oznake: sistemska toksikologija;alternative eksperimentom na živalih;mavrična postrv;ekotoksikologija;new approach methodologies (NAMs);rainbow trout cell lines;toxicity testing;socio-technical approach;co-design with stakeholders;
Given the need to reduce animal testing for environmental risk assessment, we aim to develop a fish invitrome, an alternative fish modular framework capable of predicting chemical toxicity in fish without the use of animals. The central module of the framework is the validated RTgill-W1 cell line as ...
Leto: 2025 Vir: Nacionalni inštitut za biologijo (NIB)
Izvirni znanstveni članek
Oznake: prirojene okvare imunosti;primarne imunske pomanjkljivosti;imunska disregulacija;inborn error of immunity;primary immunodeficiency;immune dysregulation;
Background. Inborn errors of immunity (IEI) are rare diseases, which makes diagnosis a challenge. A better description of the initial presenting manifestations should improve awareness and avoid diagnostic delay. Although increased infection susceptibility is a well-known initial IEI manifestation, ...
Leto: 2021 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake: Crohn’s disease;anti-TNF;drug positioning;treatment failure;treatment response;ustekinumab;vedolizumab;
Background: The effectiveness of anti-TNF or ustekinumab (UST) as a second-line biologic after vedolizumab (VDZ) failure has not yet been described. Aims and methods: In this retrospective multicenter cohort study, We aim to investigate the effectiveness of anti-TNF and UST as second-line therapy in ...
Leto: 2023 Vir: Splošna bolnišnica Celje (SB-CE)
Št. zadetkov: 3
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