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Št. zadetkov: 3
Mitochondrial connexin 43 modulates metabolic stress adaptation in glioma cell lines
Anna Gervasi, Simona Denaro, Simona D'Aprile, Maja Potokar, Jernej Jorgačevski, Robert Zorec
Izvirni znanstveni članek
Oznake: CX43;pH;geldanamycin;glioblastoma;metabolism;purine;
Background: Connexin 43 (CX43) is a hemichannel (HC)- and gap junction (GJ)-forming protein that mediates the exchange of small molecules between the intracellular and extracellular environments, as well as intercellular communication. In addition to this canonical role, recent studies have shown th ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment
Simona D'Aprile, Simona Denaro, Filippo Torrisi, Lucia Longhitano, Sebastiano Giallongo, Cesarina Giallongo, Vittorio Bontempi, Claudio Bucolo, Filippo Drago, Maria Caterina Mione, Maja Potokar, Jernej Jorgačevski, Robert Zorec
Izvirni znanstveni članek
Oznake: metabolism;purine;glioblastoma;temozolomide;treatment;
Glioblastoma (GBM) is among the deadliest cancers, characterized by poor prognosis and median survival of 12-15 months post-diagnosis. Despite aggressive therapeutic regimens, GBM treatment is still an unmet clinical need due to heterogeneity, recurrencies, and resistance. Metabolic reshaping is eme ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Phylogenomic diversity elucidates mechanistic insights into Lyme borreliae - host association
Matthew Combs, Ashley L. Marcinkiewicz, Alan P. Dupuis, April D. Davis, Patricia Lederman, Tristan A. Nowak, Jessica L. Stout, Klemen Strle, Volker Fingerle, Gabriele Margos
Izvirni znanstveni članek
Oznake: host association;Borrelia;complement;phylogenomics;plasmid diversity;
Host association—the selective adaptation of pathogens to specific host species—evolves through constant interactions between host and pathogens, leaving a lot yet to be discovered on immunological mechanisms and genomic determinants. The causative agents of Lyme disease (LD) are spirochete bacteria ...
Leto: 2022 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Št. zadetkov: 3
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