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Št. zadetkov: 7
​Imunofenotipske značilnosti limfomov T in reaktivnih limfocitov T
Veronika Kloboves Prevodnik, Simon Buček
Doktorska disertacija
Oznake: T-celični limfomi;pretočna citometrija;klonalnost limfocitov T;algoritemska analiza;T-celični kloni nejasnega pomena;
IZVLEČEK Uvod in namen: T-celični limfomi (TCL) so redka skupina ne-Hodgkinovih limfomov, za katere je značilna heterogenost, zahtevna diagnostika in slaba prognoza. Diagnoza temelji na kombinaciji kliničnih, morfoloških, imunofenotipskih in molekularnih značilnosti, pri čemer je poseben izziv razli ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Electrotransfer of siRNA to silence enhanced green fluorescent protein in tumor mediated by a high intensity pulsed electromagnetic field
Simona Kranjc, Matej Kranjc, Maja Čemažar, Simon Buček, Gregor Serša, Damijan Miklavčič
Izvirni znanstveni članek
Oznake: pulzno elektromagnetno polje;siRNA;tumorji;elektroporacija;genska terapija;pulsed electromagnetic field;tumor;electroporation;gene therapy;
The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a treated tissue to a time-varying magnetic field. D ...
Leto: 2020 Vir: Fakulteta za elektrotehniko (UL FE)
Expression of inducible damage-associated molecular patterns after interleukin-12 gene electrotransfer in mouse melanoma and colorectal cell lines
Ajda Vrabič, Maša Bošnjak, Tanja Dolinšek, Simon Buček, Gregor Serša, Maja Čemažar
Izvirni znanstveni članek
Oznake: elektroprenos genov;citokini;interlevkin-12;gene electrotransfer;cytokine;interleukin-12;
Interleukin-12 (IL-12) has demonstrated potent antitumor effects by activating natural killer (NK) and T cells, but its systemic administration poses challenges due to toxicity. This study investigated gene electrotransfer (GET) as a localized delivery method for IL-12 plasmids in B16F10 and CT26 tu ...
Leto: 2025 Vir: Onkološki inštitut Ljubljana (OI)
Electrochemotherapy with bleomycin, oxaliplatin, or cisplatin in mouse tumor models, from tumor ablation to in situ vaccination
Katja Uršič, Urška Kamenšek, Simona Kranjc, Chloe Heranney, Tilen Komel, Simon Buček, Maja Čemažar, Gregor Serša
Izvirni znanstveni članek
Oznake: elektroporacija;kemoterapevtiki;mišji tumorski modeli;electroporation;chemotherapeutic drugs;mouse tumor models;
Introduction: In addition to its direct cytotoxic effects, ablative therapies as electrochemotherapy (ECT) can elicit indirect antitumor effects by triggering immune system responses. Here, we comprehensively analyzed this dual effectiveness of intratumoral ECT with chemotherapeutic drugs bleomycin ...
Leto: 2025 Vir: Onkološki inštitut Ljubljana (OI)
ǂThe ǂprognostic significance of tumor-immune microenvironment in ascites of patients with high-grade serous carcinoma
Simona Miceska, Erik Škof, Simon Buček, Cvetka Grašič-Kuhar, Gorana Gašljević, Špela Smrkolj, Veronika Kloboves-Prevodnik
Izvirni znanstveni članek
Oznake: visoko tvegani raki;imunske celice;biološki označevalci;napovedni označevalci;high-grade serous carcinoma;immune cells;prognostic markers;
Background: High-grade serous carcinoma (HGSC) is often associated with ascites at presentation. Our objective was to quantify immune cells (ICs) in ascites prior to any treatment was given and evaluate their impact on progression-free survival (PFS) and overall survival (OS). Patients and methods: ...
Leto: 2023 Vir: Onkološki inštitut Ljubljana (OI)
Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity
Vesna Todorović, Ajda Prevc, Martina Nikšić Žakelj, Monika Štimac, Simon Buček, Blaž Grošelj, Primož Strojan, Maja Čemažar, Gregor Serša
Izvirni znanstveni članek
Oznake: DNA damage;isogenic cell lines;low dose irradiation;pulsed low dose-rate irradiation;radiosensitivity;
. Management of locoregionally recurrent head and neck squamous cell carcinomas (HNSCC) is challenging due to potential radioresistance. Pulsed low-dose rate (PLDR) irradiation exploits phenomena of increased radiosensitivity, low-dose hyperradiosensitivity (LDHRS), and inverse dose-rate effect. The ...
Leto: 2020 Vir: Onkološki inštitut Ljubljana (OI)
Potentiation of electrochemotherapy effectiveness by immunostimulation with IL-12 gene electrotransfer in mice is dependent on tumor immune status
Katja Uršič, Špela Kos, Urška Kamenšek, Maja Čemažar, Simona Miceska, Boštjan Markelc, Simon Buček, Barbara Starešinič, Veronika Kloboves-Prevodnik, Richard Heller, Gregor Serša
Izvirni znanstveni članek
Oznake: elektrokemoterapija;elektroprenos genov;interlevkin-12;electrochemotherapy;gene electrotransfer;interleukin-12;
Electrochemotherapy (ECT) exhibits high therapeutic effectiveness in the clinic, achieving up to 80% local tumor control but without a systemic (abscopal) effect. Therefore, we designed a combination therapy consisting of ECT via intratumoral application of bleomycin, oxaliplatin or cisplatin with p ...
Leto: 2021 Vir: Onkološki inštitut Ljubljana (OI)
Št. zadetkov: 7
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