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Št. zadetkov: 2
ǂA ǂputative serine protease is required to initiate the RIPK3-MLKL-mediated necroptotic death pathway in neutrophils
Xiaoliang Wang, Damjan Avsec, Aleš Obreza, Shida Yousefi, Irena Mlinarič-Raščan, Hans-Uwe Simon
Izvirni znanstveni članek
Oznake: necroptosis;neutrophil;serine protease;signal transduction;small molecule inhibitor;
Adhesion receptors, such as CD44, have been shown to activate receptor interacting protein kinase-3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling, leading to a non-apoptotic cell death in human granulocyte/macrophage colony-stimulating factor (GM-CSF) - primed neutrophils. The signaling events ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Membrane damage by MBP-1 is mediated by pore formation and amplified by mtDNA
Lea Gigon, Philipp Müller, Beat Haenni, Ioan Iacovache, Maruša Barbo, Gordana Gosheva, Shida Yousefi, Alice Soragni, Christoph von Ballmoos, Benoît Zuber, Hans-Uwe Simon
Izvirni znanstveni članek
Oznake: zunajcelična past;eozinofili;glavna bazična beljakovina;metilacija DNA;tvorba por;mitohondrijske DNA;extracellular trap;eosinophils;major basic protein;DNA methylation;mitochondrial DNA;pore formation;
Eosinophils play a crucial role in host defense while also contributing to immunopathology through the release of inflammatory mediators. Characterized by distinctive cytoplasmic granules, eosinophils securely store and rapidly release various proteins exhibiting high toxicity upon extracellular rel ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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