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Št. zadetkov: 5
Tvorba citokinov po spodbujanju makrofagov z različnimi sevi streptokov skupine B
Sara Petrin, Andreja Nataša Kopitar, Alojz Ihan
Magistrsko delo
Oznake: streptokoki skupine B;makrofagi;citokini;pretočna citometrija;
Streptokoki skupine B (GBS) so vodilni vzrok za bolezni in smrt novorojenčkov po vsem svetu. Prav tako imajo pomemben vpliv na nosečnice, starejše in imunsko oslabljene osebe. Prehod iz asimptomatske kolonizacije v invazivno okužbo še ni povsem razumljen. V naši raziskavi smo s pomočjo pretočnega ci ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Severe clinical phenotype in Alport syndrome due to two COL4A4 exon skipping events
Jerica Pleško, Nika Kojc, Špela Kert, Sara Petrin, Alenka Matjašič, Anamarija Meglič, Andrej Zupan
Kratki znanstveni prispevek
Oznake: Alport syndrome;exon skipping;whole transcriptome sequencing;kidney;COL4A4;
Alport syndrome (AS) is a genetically heterogeneous disorder caused by mutations in COL4A3, COL4A4, or COL4A5, leading to progressive renal dysfunction. While genetic screening has advanced, many cases remain undiagnosed due to deep intronic splice site variants. We report a male patient diagnosed w ...
Leto: 2025 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Identification and prioritisation of tumour antigen candidates from 79 glioblastoma transcriptomesmellitus
Špela Kert, Jože Pižem, Sara Petrin, Matic Bošnjak, Miha Jerala, Alenka Matjašič, Andrej Zupan, Andrej Zupan
Izvirni znanstveni članek
Oznake: computational immunology;glioblastoma;HLA class I;transcriptome sequencing;tumor antigens;
Glioblastoma (GBM) is an aggressive brain tumour with limited responsiveness to current immunotherapeutic approaches, partly due to its low mutational burden and intra-tumour heterogeneity. A systematic understanding of the tumour antigen landscape is therefore essential for advancing tumour immunol ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Not all Group B Streptococci are alike
Larisa Janžič, Lucija Levstek, Sara Petrin, Alojz Ihan, Andreja Nataša Kopitar, Andreja Nataša Kopitar
Izvirni znanstveni članek
Oznake: clinical isolate heterogeneity;Group B Streptococcus;immune evasion;inflammation;macrophages;preterm birth;pyroptosis;
Background: Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis and meningitis despite preventive strategies. Disease severity and clinical presentation vary widely and are influenced by strain-specific virulence traits. Macrophages are key innate immune sentinels during GBS infec ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Kidney transcriptome sequencing improves molecular diagnosis and reveals splicing complexity across the Alport spectrum
Jerica Pleško, Špela Kert, Sara Petrin, Špela Borštnar, Željka Večerić-Haler, Anamarija Meglič, Nejc Piko, Alenka Matjašič, Nika Kojc, Andrej Zupan
Izvirni znanstveni članek
Oznake: Alport spectrum;kidney transcriptomics;splicing variants;COL4A4 exon 27 skipping;
Introduction: Hereditary glomerular basement membrane (GBM) disorders caused by pathogenic variants in COL4A3/A4/A5 are increasingly recognized as Alport spectrum. Disease severity varies widely and is influenced by variant type, allelic dosage, sex, and genetic modifiers. DNA-based testing incomple ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 5
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