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Št. zadetkov: 3
Critical transitions in pancreatic islets
Dean Korošak, Sandra Postić, Andraž Stožer, Boris Podobnik, Marjan Rupnik
Izvirni znanstveni članek
Oznake: cellular organization, physiology & dynamics;phase transitions in biological systems;complex networks;endocrine system;optical microscopy;
Calcium signals in pancreatic 𝛽 cell collectives show a sharp transition from uncorrelated to correlated state resembling a phase transition as the slowly increasing glucose concentration crosses the tipping point. However, the exact nature or the order of this phase transition is not well understo ...
Leto: 2025 Vir: Medicinska fakulteta (UM MF)
Dual mode of action of acetylcholine on cytosolic calcium oscillations in pancreatic beta and acinar cells in situ
Nastja Sluga, Sandra Postić, Srdjan Sarikas, Ya-Chi Huang, Andraž Stožer, Marjan Rupnik
Izvirni znanstveni članek
Oznake: pancreas tissue slices;acetylcholine;beta cell;acinar cell;Ca2+ oscillations;
Cholinergic innervation in the pancreas controls both the release of digestive enzymes to support the intestinal digestion and absorption, as well as insulin release to promote nutrient use in the cells of the body. The effects of muscarinic receptor stimulation are described in detail for endocrine ...
Leto: 2021 Vir: Medicinska fakulteta (UM MF)
pH-dependence of glucose- dependent activity of beta cell networks in acute mouse pancreatic tissue slice
Sandra Postić, Marko Gosak, Wen-Hao Tsai, Johannes Pfabe, Srdjan Sarikas, Andraž Stožer, Dean Korošak, Shi-Bing Yang, Marjan Rupnik
Izvirni znanstveni članek
Oznake: izločanje inzulina;razdražljivost membrane;kalijevi kanali;omrežje beta celic;kolektivna dejavnost;kalcijevi valovi;insulin secretion;membrane excitability;potassium channels;beta cell network;collective activity;calcium waves;pancreatic islets;pH-dependence;
Extracellular pH has the potential to affect various aspects of the pancreatic beta cell function. To explain this effect, a number of mechanisms was proposed involving both extracellular and intracellular targets and pathways. Here, we focus on reassessing the influence of extracellular pH on gluco ...
Leto: 2022 Vir: Medicinska fakulteta (UM MF)
Št. zadetkov: 3
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