Št. zadetkov: 11
Izvirni znanstveni članek
Oznake:
inflammation;hemostasis;lipoprotein(a);rs10444872;rs3798220;KIV-2 repeats;
Lipoprotein(a) (Lp(a)) is an independent risk factor for future coronary events. Variants rs10455872 and rs3798220 in the gene encoding Lp(a) are associated with an increased Lp(a) concentration and risk of coronary artery disease. We aimed to determine whether in high-risk coronary artery disease p ...
Leto:
2024
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Pregledni znanstveni članek
Oznake:
lipoprotein(a);atherothrombosis;inflammation;coagulation;fibrinolysis;
Increased lipoprotein(a) (Lp(a)) levels are an independent predictor of coronary artery disease (CAD), degenerative aortic stenosis (DAS), and heart failure independent of CAD and DAS. Lp(a) levels are genetically determinated in an autosomal dominant mode, with great intra- and inter-ethnic diversi ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Pregledni znanstveni članek
Oznake:
atherosclerosis;monocytes;macrophages;lipoprotein(a);LDL cholesterol;
Atherosclerosis is an active interaction between lipoproteins and inflammatory cells. Monocytes and macrophages are the most important immune cells involved in the process of atherosclerosis. They interact with atherogenic lipoproteins, in particular low density lipoprotein (LDL) cholesterol and lip ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Pregledni znanstveni članek
Oznake:
lipoprotein (a);fibrinolysis;coagulation;plaque rupture;cardiovascular risk;
Lipoprotein(a) (Lp(a)) is a low-density lipoprotein (LDL)–like particle and an established independent risk factor for cardiovascular disease. Its plasma concentration and antifibrinolytic properties are largely genetically determined, primarily by variation in the LPA gene, and in particular, by th ...
Leto:
2026
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Izvirni znanstveni članek
Oznake:
inflammation;hemostasis;PCSK9 inhibitors;LDL cholesterol;lipoprotein (a);
Despite progress in treatment, elevated levels of low-density lipoprotein cholesterol (LDL-C) and lipoprotein (a) (Lp(a)), represent a significant part of the residual risk. Both are associated with inflammation and the coagulation fibrinolytic system. The purpose of our research was to evaluate the ...
Leto:
2024
Vir:
Medicinska fakulteta (UL MF)
Kratki znanstveni prispevek
Oznake:
thrombotic microangiopathy;calcineurin inhibitors;mechanistic target of rapamycin;belatacept;
Thrombotic microangiopathy (TMA) represents a heterogeneous group of disorders characterized by endothelial injury, complement activation, and platelet aggregation, and may occur in association with systemic diseases, infections, or drug exposure. In solid organ transplant recipients, TMA is most co ...
Leto:
2026
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
PCSK9 inhibitors;lipid regulators;inflammation;coagulation;coronary artery disease;
Background: PCSK9 inhibitors (PCSK9i) represent a newer form of atherosclerosis treatment. Inflammation and haemostasis are key processes in the development of atherosclerosis. In this study, we investigated the influence of therapy with PCSK9i in patients with coronary artery disease (CAD) on regul ...
Leto:
2025
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
polimorfizmi PCSK9;lipoprotein(a);endotelijska disfunkcija;skupne ravni PCSK9;PCSK9 polymorphisms;endothelial dysfunction;total PCSK9 levels;
The proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates lipid metabolism, inflammation and haemostasis. Pathogenic gain-of-function variants in the PCSK9 gene are causative of autosomal-dominant form of familial hypercholesterolemia, while several PCSK9 alleles have been associated with ...
Leto:
2025
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Tine Bajec,
Neža Žorž,
Sabina Ugovšek,
Gregor Zemljič,
Andraž Cerar,
Sabina Frljak,
Renata Okrajšek,
Petra Girandon Sušanj,
Miran Šebeštjen,
Bojan Vrtovec,
Gregor Poglajen
Izvirni znanstveni članek
Oznake:
heart failure;myocardial reverse remodeling;soluble guanylate cyclase stimulator;
Background and aims: Vericiguat lowers cardiovascular death or heart-failure hospitalization in recently worsened heart failure with reduced ejection fraction (HFrEF), but its effects on cardiac remodeling are less well characterized. Our aim was to evaluate whether the addition of vericiguat to gui ...
Leto:
2026
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Sabina Ugovšek,
Andreja Rehberger Likozar,
Tina Levstek,
Katarina Trebušak Podkrajšek,
Janja Zupan,
Frieda Marka,
Tamara Trimmel,
Mira Brekalo,
Walter Speidl,
Philipp Hohensinner,
Patrick Haider,
Miran Šebeštjen
Izvirni znanstveni članek
Oznake:
PCSK9;Lp(a);monocytes (monociti);
Background: Intermediate monocytes (IM) exhibit proinflammatory properties and contribute to atherosclerosis. Elevated lipoprotein(a) [Lp(a)] levels modulate monocyte behavior, while proprotein convertase subtilisin/kexin type 9 (PCSK9) has been implicated in inflammatory pathways beyond lipid metab ...
Leto:
2026
Vir:
Medicinska fakulteta (UL MF)