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Delayed type I interferon response and the subsequent out-of-sequence cytokine signal inhibit T cell induction in non-surviving Ebola virus-infected patients
Gang Zhao, Gang Zhao, Miša Korva, César Muñoz-Fontela, Stephan Günther, Romy Kerber, Sebastian C. Binder, Michael Meyer-Hermann, Michael Meyer-Hermann
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Oznake: Ebola virus;cytokine dynamics;innate adaptive immune crosstalk;machine learning - ML;mathematical model;sequential cytokine signaling;type I interferon;
Introduction: While there is evidence that Ebola virus (EBOV) antagonizes the antiviral type I interferon (IFN-I) response, the role of IFN-I for EBOV disease remains controversial, as initially protective responses may contribute to disease pathogenesis later. Methods: We analyzed patient data from ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
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