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Repurposing of compound libraries yields new inhibitors of NDM-1 metallo-β-lactamase with diverse zinc-binding moieties
Vid Kavaš, Philip Hinchliffe, Maša Zorman, Alen Krajnc, Matic Proj, Majda Golob, Martina Hrast, James Spencer, Stanislav Gobec
Izvirni znanstveni članek
Oznake: mercaptoamides;New Delhi metallo-β-lactamase inhibitors;zinc-binding group library;in silico design;
Antimicrobial resistance has emerged as a critical global public health threat, impacting human, animal and environmental health. An important mechanism of resistance is the production of β-lactamases, enzymes that hydrolyze the β-lactam ring, rendering β-lactam antibiotics ineffective. Metallo-β-la ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
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