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Št. zadetkov: 8
Novi radiooznačeni antagonisti holecistokinin-2/gastrinskega receptorja
Doroteja Novak, Marko Anderluh, Petra Kolenc-Peitl
Doktorska disertacija
Oznake: holecistokininski-2/gastrinski receptor;holecistokininski-1 receptor;radionuklidi;analog minigastrina;antagonisti CCK2R;sinteza na trdnem polimernem nosilcu;
Zaradi prekomernega izražanja holecistokininskega-2/gastrinskega receptorja (CCK2R) na površini celic nekaterih vrst tumorjev predstavlja CCK2R privlačno tarčo za razvoj radiooznačenih ligandov. Razvoj teh je v zadnjih letih še vedno v največjem obsegu omejen na razvoj radiooznačenih agonistov na os ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Sinteza DOTA-konjugiranih analogov in metabolitov minigastrina
Tatjana Janžovnik, Marija Sollner Dolenc, Petra Kolenc-Peitl
Diplomsko delo
Oznake: gastrin;gastrinski receptorji;radiopeptidi;DOTA konjugirani metaboliti;minigastrin;cirkularni dihroizem;metabolna stabilnost;
Sinteza DOTA-konjugiranih analogov in metabolitov minigastrina
Leto: 2012 Vir: Fakulteta za farmacijo (UL FFA)
Sinteza in radiooznačevanje analogov minigastrina, konjugiranih z različnimi bifunkcionalnimi kelatorji
Nevenka Kragelj Lapanja, Marija Sollner Dolenc, Petra Kolenc-Peitl
Magistrsko delo
Oznake: minigastrin;gastrinski receptor;diagnostika tumorjev;bifunkcionalni kelatorji;helocistokinin;radiooznačevanje z 68Ga;sinteza konjugiranih analogov;
Sinteza in radiooznačevanje analogov minigastrina, konjugiranih z različnimi bifunkcionalnimi kelatorji
Leto: 2014 Vir: Fakulteta za farmacijo (UL FFA)
Novel nastorazepide-based radioligands demonstrate excellent cholecystokinin-2 receptor targeting and theranostic potential
Lennart Bohrmann, Doroteja Novak, Marko Krošelj, Raghuvir H. Gaonkar, Francesca Porto, Fani Melpomeni, Petra Kolenc-Peitl, Marko Anderluh, Marko Anderluh, Rosalba Mansi, Rosalba Mansi
Izvirni znanstveni članek
Oznake: cholecystokinin-2 receptor antagonists;CCK2R antagonists;nastorazepide;radioligands;SPECT/CT;peptide receptor radionuclide therapy;
Radiolabeled gastrin antagonists are emerging as a new tool for the diagnosis and treatment of cholecystokinin-2 receptor (CCK2R) expressing tumors such as medullary thyroid carcinoma and small cell lung cancer, overcoming limitations of agonist-based ligands. In this study, the CCK2R antagonist nas ...
Leto: 2026 Vir: Repozitorij Univerze v Ljubljani (RUL)
Calcitonin and procalcitonin measurement after cholecystokinin-2/gastrin receptor agonist stimulation in patients with advanced medullary thyroid cancer
Malgorzata Trofimiuk‑Müldner, Katica Bajuk-Studen, Paola Erba, Luka Ležaič, Clemens Decristoforo, Katja Zaletel, Petra Kolenc-Peitl, Elwira Przybylik‑Mazurek, Irene Virgolini
Izvirni znanstveni članek
Oznake: medullary thyroid cancer;calcitonin;procalcitonin;cholecystokinin-2/gastrin receptor agonist;
Introduction: Medullary thyroid cancer (MTC) is characterized by overexpression of cholecystokinin-2/gastrin receptors (CCK2R). There are limitations of calcitonin as a tumor marker in MTC diagnosis and prognosis. Procalcitonin is gaining a role as a complementary tumor marker. This study aimed to a ...
Leto: 2025 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
[111In]In-CP04 as a novel cholecystokinin-2 receptor ligand with theranostic potential in patients with progressive or metastatic medullary thyroid cancer
Luka Ležaič, Paola Erba, Clemens Decristoforo, Katja Zaletel, Renata Mikolajczak, Helmut R. Maecke, Theodosia Maina, Mark W. Konijnenberg, Petra Kolenc-Peitl, Malgorzata Trofimiuk‑Müldner
Izvirni znanstveni članek
Oznake: onkologija;rak ščitnice;molekularni pregled;terapija;
Introduction: Medullary thyroid cancer (MTC) is a rare malignant tumour of the parafollicular C-cells with an unpredictable clinical course and currently suboptimal diagnostic and therapeutic options, in particular in advanced disease. Overexpression of cholecystokinin-2 receptors (CCK2R) represents ...
Leto: 2023 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Recommendations on the clinical application and future potential of α-particle therapy
Valentina Di Iorio, Anna Sarnelli, Stefano Boschi, Maddalena Sansovini, Rosa Maria Genovese, Cipriana Stefanescu, Vlad Ghizdovat, Wael Jalloul, Jennifer A. Young, Petra Kolenc-Peitl
Pregledni znanstveni članek
Oznake: TAT;α-emitters;actinium-225;bismuth-213;astatine-211;lead-212;terbium-149;radium-223;thorium-227;
This review comprehensively assesses the clinical applications and future potential of alpha-emitting radionuclides available for targeted alpha-particle therapy (TAT) in cancer treatment. The approval of radium-223 therapy in 2013 marked a significant advancement in alpha-emitting therapeutic radio ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Development of the 99mTc-labelled SST2 antagonist TECANT-1 for a first-in-man multicentre clinical study
Doroteja Novak, Barbara Janota, Anton Amadeus Hörmann, Agnieszka Sawicka, Marko Krošelj, Alicja Hubalewska-Dydejczyk, Melpomeni Fani, Renata Mikolajczak, Petra Kolenc-Peitl, Clemens Decristoforo, Piotr Garnuszek
Izvirni znanstveni članek
Oznake: tehnecij-99m;antagonisti receptorjev somatostatina;formulacija kompleta;toksičnost enkratnega odmerka;SPECT;radiofarmacevtiki;nevroendokrine neoplazme;technetium-99m;somatostatin receptor antagonists;kit formulation;single dose toxicity;radiopharmaceuticals;neuroendocrine neoplasms;
Broad availability and cost-effectiveness of 99Mo/99mTc generators worldwide support the use, and thus the development, of novel 99mTc-labelled radiopharmaceuticals. In recent years, preclinical and clinical developments for neuroendocrine neoplasms patient management focused on somatostatin recepto ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 8
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