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Št. zadetkov: 2
Effect of diflunisal and purine synthesis inhibitors on AMP-activated protein kinase and insulin action in skeletal muscle cells
Klemen Dolinar, Sergej Pirkmajer, Pablo Miguel Garcia-Roves
Doktorska disertacija
Oznake: AMP-activated protein kinase (AMPK);diflunisal;inhibitors of de novo purine synthesis;inhibitors of folate metabolism;insulin;skeletal muscle cells;
BACKGROUND: Skeletal muscles are an important site of glucose uptake and utilization and therefore play an important role in whole-body glucose homeostasis, making them an important target for the treatment of diabetes. One promising approach for the treatment of diabetes is activation of AMP-activa ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
Diverse inhibitors of de novo purine synthesis promote AICAR-induced AMPK activation and glucose uptake in L6 myotubes
Klemen Dolinar, Katarina Miš, Katja Šopar, Mateja Šutar, Meta Božič, Matic Kolar, Tim Hropot, Pablo Miguel Garcia-Roves, Alexander V. Chibalin, Sergej Pirkmajer, Sergej Pirkmajer
Izvirni znanstveni članek
Oznake: AMP‐activated protein kinase (AMPK);folate metabolism;glucose uptake;insulin signaling;purine metabolism;skeletal muscle cells;
Methotrexate, an immunosuppressant and anticancer drug, promotes glucose uptake and lipid oxidation in skeletal muscle via activation of AMP-activated protein kinase (AMPK). Methotrexate promotes AMPK activation by inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide (ZMP) formyltransferase/inos ...
Leto: 2025 Vir: Repozitorij Univerze v Ljubljani (RUL)
Št. zadetkov: 2
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