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Št. zadetkov: 2
Stefin B and cystatin C deficiency suppresses tumor growth and alters tumor microenvironment in a breast cancer model
Petra Matjan-Štefin, Janja Završnik, Miha Butinar, Georgy Mikhaylov, Boris Turk, Olga Vasiljeva
Izvirni znanstveni članek
Oznake: cistatin C;stefin B;mikrookolje tumorja;cisteinski katepsini;metabolizem raka;cystatin C;tumor microenvironment;cysteine cathepsins;cancer metabolism;protease inhibitors;
Background/Objectives: Cysteine cathepsins and their endogenous inhibitors have been shown to possess context-dependent functions in cancer progression, including the regulation of tumor metabolic pathways. Stefin B and cystatin C, intracellular and extracellular protease inhibitors, respectively, c ...
Leto: 2026 Vir: Institut Jožef Stefan (IJS)
Structural and proteomic analysis of the mouse cathepsin B-DARPin 4m3 complex reveals species-specific binding determinants
Miki Zarić, Livija Tušar, Lovro Kramer, Lovro Kramer, Olga Vasiljeva, Matej Novak, Francis Impens, Aleksandra Usenik, Kris Gevaert, Dušan Turk, Boris Turk
Izvirni znanstveni članek
Oznake: katepsin B;proteomika;zaviralci;cathepsin B;protein inhibitor;proteomics;
Cathepsin B (CatB) is a lysosomal cysteine protease that plays a major role in various pathologies and is therefore considered a valuable therapeutic target. To address species-specific inhibitor challenges, we characterized the selective binding of designed ankyrin repeat protein (DARPin) 4m3 towar ...
Leto: 2025 Vir: Institut Jožef Stefan (IJS)
Št. zadetkov: 2
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