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Structural and proteomic analysis of the mouse cathepsin B-DARPin 4m3 complex reveals species-specific binding determinants
Miki Zarić, Livija Tušar, Lovro Kramer, Lovro Kramer, Olga Vasiljeva, Matej Novak, Francis Impens, Aleksandra Usenik, Kris Gevaert, Dušan Turk, Boris Turk
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Oznake: katepsin B;proteomika;zaviralci;cathepsin B;protein inhibitor;proteomics;
Cathepsin B (CatB) is a lysosomal cysteine protease that plays a major role in various pathologies and is therefore considered a valuable therapeutic target. To address species-specific inhibitor challenges, we characterized the selective binding of designed ankyrin repeat protein (DARPin) 4m3 towar ...
Leto: 2025 Vir: Institut Jožef Stefan (IJS)
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