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Mapping functionally relevant tractable lysines of challenging protein targets by covalent fragment screening
Noémi Csorba, Péter Ábrányi-Balogh, Zoltán Orgován, Tibor Viktor Szalai, György G. Ferenczy, Levente Kollár, Nikolett Péczka, Tímea Imre, József Simon, Martina Hrast, Stanislav Gobec
Izvirni znanstveni članek
Oznake: allosteric sites;covalent fragment;electrophilic warhead;lysine labelling;protein–protein interaction;
Covalent fragment screening has become an established strategy for identifying targetable amino acid residues or viable chemical starting points against challenging protein targets. In recent years, lysine has received growing interest as a nucleophilic residue suitable for covalent labelling. Herei ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
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