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Št. zadetkov: 7
Genotipizacija sevov vrste Escherichia coli, ki izločajo betalaktamaze z razširjenim spektrom delovanja, izoliranih iz hemokultur in nadzornih kužnin
Nika Gobec, Jerneja Ambrožič, Mateja Pirš, Katja Seme
Magistrsko delo
Oznake: Escherichia coli;betalaktamaze;ESBL;genotipizacija;nadzorna kužnina;hemokultura;
V naši raziskavi smo analizirali 132 ESBL-pozitivnih izolatov E. coli, vzorčenih pri 66 bolnikih iz Osrednjeslovenske regije in izoliranih na Inštitutu za mikrobiologijo in imunologijo Medicinske fakultete Univerze v Ljubljani. V raziskavo smo vključili izolate bolnikov, pri katerih je bila ESBL-poz ...
Leto: 2022 Vir: Biotehniška fakulteta (UL BF)
Synthesis of 3-amino-4-substituted monocyclic ß-lactams - important structural motifs in medicinal chemistry
Katarina Grabrijan, Nika Strašek, Stanislav Gobec
Izvirni znanstveni članek
Oznake: monociklični ß-laktam;Staudingerjeva [2+2] ciklokondenzacija;cerijev amonijev nitrat;hidrazin hidrat;3-amino-4-substituiran azetidin-2-on;inhibitorna aktivnost;monocyclic ß-lactam;Staudinger [2+2] cyclocondensation;cerium ammonium nitrate;hydrazine hydrate;3-amino-4-substituted azetidin-2-one;inhibitory activities;
Monocyclic ß-lactams (azetidin-2-ones) exhibit a wide range of biological activities, the most important of which are antibacterial, anticancer, and cholesterol absorption inhibitory activities. The synthesis of decorated monocyclic ß-lactams is challenging because their ring is highly constrained a ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
α-Aminoboronic acid moieties in boro dipeptides modulate proteasome subunit selectivity and provide access to compounds with potent anticancer and anti-inflammatory activity
Nika Strašek, Andrej Šterman, Lara Smrdel, Stane Pajk, Stanislav Gobec, Zdenko Časar, Martina Gobec, Izidor Sosič
Izvirni znanstveni članek
Oznake: proteasomi;homeostaza;celične beljakovine;antikancerogeno delovanje;protivnetno delovanje;proteasomes;homeostasis;cellular proteins;anticancer activity;anti-inflammatory activities;
Proteasomes regulate cellular protein homeostasis and are key targets in treating cancer, inflammation, and autoimmune diseases. The two main forms, the constitutive proteasome and immunoproteasome, each contain three catalytically active subunits with distinct substrate specificities. The first app ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Vrednotenje himernih razgrajevalcev proteina TAK 1 na človeški epitelijski celični liniji raka dojk MDA-MB 231
Zoja Tot, Martina Gobec, Nika Strašek Benedik
Magistrsko delo
Oznake: Protein TAK1;himerni razgrajevalci;celična linija MDA-MB 231;prenos western.;
S TGF-β aktivirana kinaza 1 (TAK1) je eden izmed osrednjih regulatorjev celične smrti, ki se aktivira z različnimi znotraj- in zunajceličnimi dražljaji. TAK1 je nujen člen v signalni poti tumor nekrotizirajočega faktorja (TNF), interlevkina 1 (IL-1) in Toll-u podobnih receptorjev (TLR). Njegovo neur ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies
Matic Proj, Mitja Zidar, Blaž Lebar, Nika Strašek, Goran Miličić, Aleš Žula, Stanislav Gobec
Izvirni znanstveni članek
Oznake: viscosity;protein formulations;biopharmaceuticals;viscosity-reducing agents;computational screening;
For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here, we applied two computational chemistry approaches ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic ß-lactams as inhibitors of penicillin-binding protein(s)
Katarina Grabrijan, Nika Strašek, Alen Krajnc, Krištof Bozovičar, Damijan Knez, Matic Proj, Irena Zdovc, Izidor Sosič, Martina Hrast, Stanislav Gobec
Izvirni znanstveni članek
Oznake: antibacterial agents;monocyclic-β-lactams;penicillin-binding proteins;covalent inhibitors;transpeptidase;
In the final phases of bacterial cell wall synthesis, penicillin-binding proteins (PBPs) catalyze the cross-linking of peptidoglycan. For many decades, effective and non-toxic β-lactam antibiotics have been successfully used as mimetics of the d-Ala-d-Ala moiety of the natural substrate and employed ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Lead optimization of a butyrylcholinesterase inhibitor for the treatment of Alzheimer’s disease
Urban Košak, Nika Strašek, Damijan Knez, Simon Žakelj, Jurij Trontelj, Anja Hafner, Selena Horvat, Aljoša Bolje, Neža Žnidaršič, Neža Grgurevič, Tanja Švara, Jakob Kljun, Jure Stojan, Stanislav Gobec
Izvirni znanstveni članek
Oznake: centralni živčni sistem;odkrivanje zdravil;inhibitorji;presejalni testi;sulfoni;central nervous system;drug discovery;inhibitors;screening assays;sulfones;
Butyrylcholinesterase (BChE) is a promising drug target for alleviating the symptoms of canine cognitive dysfunction (CCD) and Alzheimer’s disease (AD). We have recently developed lead compound 2, a racemic, nanomolar BChE inhibitor with procognitive effects in mice with scopolamine-induced AD-like ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 7
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