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Št. zadetkov: 2
Sporadic Creutzfeldt-Jakob Disease is associated with reorganization of metabolic connectivity in a pathological brain network
Tomaž Rus, Jernej Mlakar, Luka Ležaič, An Vo, Nha Nguyen, Chris Chengke Tang, Michele Fiorini, Elena Prieto, Gloria Martí Andrés, Javier Arbizu, David Eidelberg, Maja Trošt
Izvirni znanstveni članek
Oznake: nevrologija;Creutzfeldt-Jakobova bolezen;
Background and purpose: Although sporadic Creutzfeldt–Jakob disease (sCJD) is a rare cause of dementia, it is critical to understand its functional networks as the prion protein spread throughout the brain may share similar mechanisms with other more common neurodegenerative disorders. In this study ...
Leto: 2022 Vir: Medicinska fakulteta (UL MF)
MFSD7c functions as a transporter of choline at the blood-brain barrier
Xuan Thi Anh Nguyen, Thanh Nha Uyen Le, Toan Quoc Nguyen, Hoa Thi Thuy Ha, Anna Artati, Nancy C P Leong, Dat T Nguyen, Pei Yen Lim, Adelia Vicanatalita Susanto, Qianhui Huang, Jerzy Adamski
Izvirni znanstveni članek
Oznake: choline;blood-brain barrier;endothelial cells;MFSD7c;
Mutations in the orphan transporter MFSD7c (also known as Flvcr2), are linked to Fowler syndrome. Here, we used Mfsd7c knockout (Mfsd7c-/-) mice and cell-based assays to reveal that MFSD7c is a choline transporter at the blood-brain barrier (BBB). We performed comprehensive metabolomics analysis and ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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