Št. zadetkov: 507
Izvirni znanstveni članek
Oznake:
PROTAC;targeted protein degradation;SMARCA2;SMARCA4;cancer;oral bioavailability;
Selective targeting SMARCA2 by degradation represents a promising new therapeutic strategy for human cancers harboring deficient SMARCA4. Herein we report the discovery of highly potent, selective and oral available SMARCA2 PROTAC degraders, as exemplified by SMD-6346. SMD-6346 achieves DC50 = 3.3 n ...
Leto:
2026
Vir:
Fakulteta za matematiko, naravoslovje in informacijske tehnologije Koper (UP FAMNIT)
Izvirni znanstveni članek
Oznake:
PROTAC;targeted protein degradation;STAT3;cereblon;cancer;drug discovery;
Signalni prenašalec in aktivator transkripcije 3 (STAT3) je obetavna terapevtska tarča za zdravljenje rakavih obolenj in drugih bolezni pri ljudeh. V tej raziskavi predstavljamo načrtovanje, sintezo in vrednotenje novih razgrajevalcev STAT3 na osnovi tehnologije PROTAC, pri čemer smo uporabili ligan ...
Leto:
2026
Vir:
Fakulteta za matematiko, naravoslovje in informacijske tehnologije Koper (UP FAMNIT)
Izvirni znanstveni članek
Oznake:
Leto:
2011
Vir:
dLib.si Digitalna knjižnica Slovenije
Izvirni znanstveni članek
Oznake:
TiSiCN;multi-arc ion plating;magnetron sputtering;N[sub]2/Ar flow ratio;mechanical properties;tribological properties;
Effect of the N[sub]2/Ar flow ratio on the microstructure and mechanical properties of TiSiCN coatings
Leto:
2021
Vir:
Inštitut za kovinske materiale in tehnologije (IMT)
Izvirni znanstveni članek
Oznake:
radiology;case reports;methodology;guidelines;
Leto:
2024
Vir:
Digitalni repozitorij raziskovalnih organizacij Slovenije
Izvirni znanstveni članek
Oznake:
dinamično razporejanje;proizvodnja;pogajalski mehanizmi;perturbacije;
Leto:
2012
Vir:
dLib.si Digitalna knjižnica Slovenije
Pregledni znanstveni članek
Oznake:
kooperacija;sociološke mreže;evolucijske igre;kolektivni pojav;samo-organizacija;fazni prehodi;recipročnost;fizika socioloških sistemov;cooperation;social networks;evolutionary games;collective phenomena;self-organization;phase transitions;reciprocity;physics of social systems;
Networks form the backbone of many complex systems, ranging from the Internet to human societies. Accordingly, not only is the range of our interactions limited and thus best described and modeled by networks, it is also a fact that the networks that are an integral part of such models are often int ...
Leto:
2015
Vir:
Fakulteta za naravoslovje in matematiko (UM FNM)
Izvirni znanstveni članek
Oznake:
functionally graded porous nanocomposites;graphene platelets;pores;nonlinear elastic foundation;nonlinear vibration;transient response;
This paper presents a nonlinear vibration analysis of functionally graded graphene platelet (GPL) reinforced plates on nonlinear elastic foundations. Uniformly or non-uniformly distributed internal pores were present in the plates. Based on the modified Halpin-Tsai micromechanics model and the exten ...
Leto:
2022
Vir:
Fakulteta za strojništvo (UL FS)
Izvirni znanstveni članek
Oznake:
thrust cylindrical roller bearings;single pit texture;compound pit texture;friction force;wear;friction-induced vibration;noise;
To improve the reliability and service life of thrust cylindrical roller bearings (TCRBs), the effects of single/compound pit texture on tribological properties and on friction-induced vibration and noise were studied. Laser marking equipment was used to create compound pit texture on a shaft washer ...
Leto:
2023
Vir:
Fakulteta za strojništvo (UL FS)
Izvirni znanstveni članek
Oznake:
SENet;multiscale convolutional neural networks;gate recurrent unit;rolling bearings;fault diagnosis;
In this paper, a novel fault diagnosis method based on the fusion of squeeze and excitation-multiscale convolutional neural networks (SENet-MSCNN) and gate recurrent unit (GRU) is proposed to address the problem of low diagnosis rate caused by the fact that normal samples are much larger than fault ...
Leto:
2023
Vir:
Fakulteta za strojništvo (UL FS)