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Št. zadetkov: 2
Application of the Horner−Wadsworth−Emmons Olefination in the Construction of E‑α,β-Unsaturated β‑Boryl Nitriles
Kaja Gosak, Martin Črnugelj, Zdenko Časar
Izvirni znanstveni članek
Oznake: olefination;boryl nitriles;
Herein, we describe a simple transition-metal-free synthesis of E-α,β-unsaturated β-boryl nitriles by the Horner−Wadsworth−Emmons reaction starting from potassium acyltrifluoroborates. The methodology encompasses a broad range of alkyl and aryl substrates. The reaction conditions are simple, and the ...
Leto: 2025 Vir: Repozitorij Univerze v Ljubljani (RUL)
On the stability and degradation pathways of venetoclax under stress conditions
Nina Žigart, Martin Črnugelj, Janez Ilaš, Zdenko Časar
Izvirni znanstveni članek
Oznake: stability;stress testing;degradation;venetoclax;
Venetoclax is an orally bioavailable, B-cell lymphoma-2 (BCL-2) selective inhibitor, used for the treatment of various types of blood cancers, such as chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). In this study we investigated the degradation of venetoclax under various st ...
Leto: 2020 Vir: Repozitorij Univerze v Ljubljani (RUL)
Št. zadetkov: 2
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