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Št. zadetkov: 2
Design, synthesis and evaluation of a novel fluorescent probe for competitive fluorescence polarization assay to screen galectin-8 inhibitors
Edvin Purić, Marina Marinovich, Zala Kojek, Barbro Kahl-Knutson, Hakon Leffler, Ulf Nilsson, Marko Anderluh, Janez Mravljak
Kratki znanstveni prispevek
Oznake: fluorescence polarisation assay;carbohydrates;lectins;galectin-8;
In the present work, we describe the design, synthesis and evaluation of a galectin-8-binding fluorescent probe designed for a competitive fluorescence polarization (FP) assay for screening new galectin-8N inhibitors. The probe was characterized for its photophysical properties and its binding affin ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids
Goran Poje, Davor Šakić, Marina Marinovich, Jiangyang You, Michael Tarpley, Kevin P. Williams, Nikolina Golub, Jaka Dernovšek, Tihomir Tomašić, Erim Bešić, Zrinka Rajić
Izvirni znanstveni članek
Oznake: harmine;β-carboline;ferrocene;hybrid compounds;antiproliferative activity;glioblastoma multiforme;Hsp90;DYRK1A;antioxidant activity;EPR spectroscopy;
The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β-carboline and ferrocene moiety, we investigated th ...
Leto: 2024 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 2
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