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Št. zadetkov: 2
Bioinformatic and clinical experimental assay uncovers resistance and susceptibility mechanisms of human glioblastomas to temozolomide and identifies new combined and individual survival biomarkers outperforming MGMT promoter methylation
Alexander Modestov, Marianna Zolotovskaia, Maria Suntsova, Galina Zakharova, Aleksander Seryakov, Ivana Jovchevska, Jernej Mlakar, Elena Poddubskaya, Aleksey Moisseev, Grigory Vykhodtsev
Izvirni znanstveni članek
Oznake: DNA repair pathways;MGMT;Oncobox drug score;WHO CNS5;gene expression biomarker;glioblastoma;
Background: Glioblastoma (GBM) is the most aggressive and lethal central nervous system (CNS) tumor. The treatment strategy is mainly surgery and/or radiation therapy, both combined with adjuvant temozolomide (TMZ) chemotherapy. Historically, methylation of MGMT gene promoter is used as the major bi ...
Leto: 2024 Vir: Medicinska fakulteta (UL MF)
Large-scale transcriptomics-driven approach revealed overexpression of CRNDE as a poor survival prognosis biomarker in glioblastoma
Maxim Sorokin, Mikhail Raevskiy, Alja Zottel, Neja Zupanec, Marija Skoblar Vidmar, Alenka Matjašič, Andrej Zupan, Jernej Mlakar, Maria Suntsova, Denis V. Kuzmin, Anton A. Buzdin, Ivana Jovchevska
Izvirni znanstveni članek
Oznake: glioblastom;nekodirajoča RNA;dolgoročno preživetje;glioblastoma;noncoding RNA;long-term survival;
Glioblastoma is the most common and malignant brain malignancy worldwide, with a 10-year survival of only 0.7%. Aggressive multimodal treatment is not enough to increase life expectancy and provide good quality of life for glioblastoma patients. In addition, despite decades of research, there are no ...
Leto: 2021 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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