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Purine metabolism rewiring improves glioblastoma susceptibility to temozolomide treatment
Simona D'Aprile, Simona Denaro, Filippo Torrisi, Lucia Longhitano, Sebastiano Giallongo, Cesarina Giallongo, Vittorio Bontempi, Claudio Bucolo, Filippo Drago, Maria Caterina Mione, Maja Potokar, Jernej Jorgačevski, Robert Zorec
Izvirni znanstveni članek
Oznake: metabolism;purine;glioblastoma;temozolomide;treatment;
Glioblastoma (GBM) is among the deadliest cancers, characterized by poor prognosis and median survival of 12-15 months post-diagnosis. Despite aggressive therapeutic regimens, GBM treatment is still an unmet clinical need due to heterogeneity, recurrencies, and resistance. Metabolic reshaping is eme ...
Leto: 2025 Vir: Medicinska fakulteta (UL MF)
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