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Št. zadetkov: 29
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D. Hartmann, Christian Steinebach
Izvirni znanstveni članek
Oznake: the Petasis borono-Mannich reaction;Strecker synthesis;CRBN ligands;
The Petasis borono-Mannich reaction was employed for an alternative entry towards three-branched cereblon ligands. Such compounds are capabable of making multiple interactions with the protein surface and possess a suitable linker exit vector. The high-affinity ligands were used to assemble prototyp ...
Leto: 2023 Vir: Fakulteta za farmacijo (UL FFA)
Fluorinated aminopiperidones as non-glutarimide thalidomide analogs
Boštjan Adamlje, Tihomir Tomašić, Christian Steinebach, Sebastian Ebeling, Alexander Herrmann, Marcus D. Hartmann, Jessica L. Horner, Kinjal Bhadresha, Izidor Sosič, Izidor Sosič, Andrej Emanuel Cotman, Andrej Emanuel Cotman
Izvirni znanstveni članek
Oznake: bioisosterism;diastereoselectivity;drug design;fluorine;PROTAC;
The glutarimide fragment is a key pharmacophore in cereblon-binding immunomodulatory drugs and proteolysis-targeting chimeras, yet exploration of non-glutarimide scaffolds remains limited. Here, we report the design, synthesis, and evaluation of fluorinated aminopiperidones as three-dimensional, non ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
Madagaskar u. die Inseln Seychellen, Aldabra, Komoren u. Maskarenen (mit 23 Vollbildern)
R. Hartmann
Ni določena
Oznake: Völkerkunde;
Leto: 1886 Vir: dLib.si Digitalna knjižnica Slovenije
The Rat Vibrissal Array as a Model Sensorimotor System
Mitra Hartmann
Video in druga učna gradiva
Oznake: biology;neuroscience;computer science;artificial intelligence
The rat whisker (vibrissal) system has neural processing pathways that are analogous to human tactile pathways through the spinal cord. Rats use rhythmic (5-25 Hz) movements of their whiskers to actually extract object features, including size, shape, orientation, and texture. In this talk, I will d ...
Leto: 2009 Vir: videolectures.net
HHF, Switzerland
Simon Hartmann
Video in druga učna gradiva
Oznake: architecture
Simon Hartmann is a Swiss architect and one of the founding partners of HHF architects based in Basel since 2003. His office belongs to a group of emerging Swiss practices that represent a third generation in the phenomenal history of recent Swiss Architecture during the past 30 years. The first gen ...
Leto: 2011 Vir: videolectures.net
Interregional Innovation Policy in South East Europe: Past Experiences and Prospects for the Future
Christian Hartmann
Video in druga učna gradiva
Oznake: technology;innovation
Leto: 2009 Vir: videolectures.net
ǂThe ǂimpact of unilateral BIT terminations on FDI
Simon Hartmann, Rok Spruk
Izvirni znanstveni članek
Oznake: podjetništvo;Indija;direktne investicije;entrepreneurship;India;direct investments;
This study identifies the impact of Bilateral Investment Treaties (BITs) on foreign direct investments (FDI) by taking advantage of the random timing of 44 unilateral BIT terminations in India between 2013 and 2019. Using quarterly bilateral data of 138 foreign investors’ home countries (FIHCs), our ...
Leto: 2022 Vir: Ekonomska fakulteta (UL EF)
Coherence-based measures of explanatory power
Stephan Hartmann, Borut Trpin
Izvirni znanstveni članek
Oznake: razlagalna moč;verjetnostne mere;koherenca;Bayesovo sklepanje;znanstvene razlage;explanatory power;probabilistic measures;coherence;Bayesian reasoning;scientific explanation;
Recent critiques have cast doubt on the viability of probabilistic measures of ex planatory power. We respond by developing a coherence-based family of measures that sidesteps these challenges. Rather than assessing explanatory power solely by how well a hypothesis accounts for the evidence, these m ...
Leto: 2026 Vir: Filozofska fakulteta (UM FF)
Why coherence matters
Stephan Hartmann, Borut Trpin
Izvirni znanstveni članek
Oznake: epistemologija;koherentizem;spoznavni principi;resnica;epistemology;coherentism;epistemic principles;truth;
Leto: 2026 Vir: Filozofska fakulteta (UL FF)
Technik
Elke Hartmann, Elke Hartmann, Christian Hein, Christian Hein, Elisabeth Klaus, Rolf Münchow, Martina Schramm, Wolfgang Stenzel, Volker Torgau, Bernd Wöhlbrandt, Marko Marhl, Branko Kaučič
Enciklopedija, slovar, leksikon, priročnik, atlas, zemljevid
Oznake: tehnika;pouk;didaktika;priročniki;ne zaključna dela;
Technik
Leto: 2001 Vir: Pedagoška fakulteta (UM PEF)
Št. zadetkov: 29
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