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Št. zadetkov: 3
TEM images of HepG2 spheroids exposed to magnetic Ferite-based Nanoparticles MxFe3-xO4 (M=Fe, Zn, Mn) for 24 and 96 hours
Marco A. Morales Ovalle, Iza Rozman, Alja Štraser, Gerardo F. Goya, Álvaro Gallo-Cordova, María del Puerto Morales, Bojana Žegura
Raziskovalni podatki
Oznake: TEM;nanodelci na osnovi ferita;HepG2 sferoidi;internalizacija;bioakumulacija;ferrite-based nanoparticles;HepG2 spheroids;internalization;bioaccumulation;
Nanosized spinel-type ferrites have gained recognition as a unique class of engineered nanomaterials with promising applications, but their safety profiles remain insufficiently explored. Although iron (Fe), zinc (Zn), and manganese (Mn) are biologically relevant elements, the use of Zn- and Mn-cont ...
Leto: 2025 Vir: Nacionalni inštitut za biologijo (NIB)
Glucose coated FeO@Fe3O4 nanoparticles show tunable catalytic reactivity and safety in a 3D hepatic in vitro model
Marco A. Morales Ovalle, Iza Rozman, Elin L. Winkler, Enio Lima, Alja Štraser, Katja Kološa, Bojana Žegura, Gerardo F. Goya
Izvirni znanstveni članek
Oznake: 3D in vitro modeli;citotoksičnost;genotoksičnost;magnetni nanodelci;fizikalno-kemijska karakterizacija;iron-oxide nanoparticles;Fenton-like catalysis;cytotoxicity;genotoxicity;HepG2 spheroids;
Iron-oxide magnetic nanoparticles (MNPs) have been extensively investigated as magnetically actuated nanocatalysts for diagnostic and therapeutic applications. However, because wüstite/magnetite/maghemite phases can interconvert, coexisting Fe2+/Fe3+ species may redirect Fenton-like chemistry and ge ...
Leto: 2026 Vir: Nacionalni inštitut za biologijo (NIB)
Safety of ferrite nanoparticles for biomedical applications: cyto- and genotoxic effects of MxFe3-xO4 (M = Fe, Zn, Mn) in an advanced 3D human hepatic in vitro model
Iza Rozman, Álvaro Gallo-Cordova, María del Puerto Morales, Marco A. Morales Ovalle, Gerardo F. Goya, Katja Kološa, Domen Hočevar, Bojana Žegura, Alja Štraser
Izvirni znanstveni članek
Oznake: poškodba DNK;genotoksičnost;HepG2 sferoidi;magnetni nanodelci na osnovi ferita;indukcija ROS;ocena varnosti;toksikogenomika;DNA damage;genotoxicity;HepG2 spheroids;magnetic ferrite-based nanoparticles;ROS induction;safety assessment;toxicogenomics;
Given the growing interest in nanosized spinel-type ferrite nanoparticles for biomedical applications and the limited information on their safety, this study aimed to assess their cellular and genotoxic effects in an in vitro 3D human hepatic cell model (HepG2 spheroids). Ferrite nanoparticles – γFe ...
Leto: 2026 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 3
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