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Št. zadetkov: 2
Chronic disruption of the late cholesterol synthesis leads to female-prevalent liver cancer
Kaja Blagotinšek Cokan, Žiga Urlep, Gregor Lorbek, Madlen Matz-Soja, Cene Skubic, Martina Perše, Jera Jeruc, Peter Juvan, Tadeja Režen, Damjana Rozman
Izvirni znanstveni članek
Oznake: biosinteza holesterola;hepatocelularni karcinom;spolni dimorfizem;cholesterol biosynthesis;hepatocellular carcinoma;sex dimorphism;
While the role of cholesterol in liver carcinogenesis remains controversial, hepatocellular carcinoma generally prevails in males. Herein, we uncover pathways of female-prevalent progression to hepatocellular carcinoma due to chronic repression of cholesterogenic lanosterol 14[alpha]-demethylase (CY ...
Leto: 2020 Vir: Medicinska fakulteta (UL MF)
Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis
Tinkara Kreft, Kaja Blagotinšek Cokan, Cene Skubic, Tadeja Režen, Martina Perše, Karmen Wechtersbach, Nika Kojc, Jera Jeruc, Željko Debeljak, Marija Heffer, Madlen Matz-Soja, Damjana Rozman, Damjana Rozman
Izvirni znanstveni članek
Oznake: CYP51;cholesterol metabolism;crystals;cytochrome P450;lanosterol 14α-demethylase;lipid droplets;liver;mouse model;sterol;
Lanosterol 14α-demethylase (CYP51), a key enzyme in cholesterol synthesis, is essential for normal liver function. Reduced CYP51 activity leads to metabolism-associated liver disease and ultimately hepatocellular carcinoma, yet the hepatocellular processes most affected and their crosstalk with othe ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Št. zadetkov: 2
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