Št. zadetkov: 9
Izvirni znanstveni članek
Oznake:
elektrode;genska elektrotransfekcija;koničasta komora;CHO celična linija;electrodes;gene electrotransfer;pipette tip;CHO cell line;
Pipette tip with integrated electrodes for gene electrotransfer of cells in suspension
Leto:
2011
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Magistrsko delo
Oznake:
gensko spremenjeni organizem;varnostni razred;zaprti sistem;kontaminacija;zadrževalni ukrepi;
Gensko spremenjeni organizem (GSO) je organizem, z izjemo človeka, ali mikroorganizem, katerega genski material je spremenjen s postopki, ki spreminjajo genski material drugače, kot to poteka v naravnih razmerah. Lahko je potencialno nevaren, toksičen, ali ima možnost nenadzorovanega širjenja. GSO r ...
Leto:
2021
Vir:
Fakulteta za farmacijo (UL FFA)
Pregledni znanstveni članek
Oznake:
celični modeli in vitro;limfoblastoidne celične linije;predklinične študije;personalizirana medicina;
Personalizirana medicina temelji na prilagajanju zdravljenja genotipu in fenotipu posameznika z namenom povečanja učinkovitosti terapije in zmanjšanja tveganja za neželene učinke. Pomembno vlogo pri njenem uveljavljanju imajo ustrezni predklinični modeli in vitro, ki omogočajo sistematično proučevan ...
Leto:
2026
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Izvirni znanstveni članek
Oznake:
hypotonic treatment;cell swelling;regulatory volume decrease;cell size measurements;viability;electrofusion;electroporation;
Background. Various electrofusion parameters have to be adjusted to obtain theoptimal electrofusion efficiency. Based on published data, good electrofusion conditions can be achieved with the hypotonic treatment. However, the duration of the hypotonic treatment before electroporation and buffer hypo ...
Leto:
2009
Vir:
Repozitorij Univerze v Ljubljani (RUL)
Izvirni znanstveni članek
Oznake:
citokinska nevihta;limfoblastoidne celične linije;LCL celice;imunomodulatorji presejalni testi za zdravila;prenamenitev zdravil;medindividualna variabilnost;cytokine storm;lymphoblastoid cell lines;LCL cells;immunomodulatory drug screening;Drug repurposing;interindividual variability;
Cytokine storm, a life-threatening hyperinflammatory response seen in severe infections like COVID-19, autoimmune diseases, and certain therapies, remains difficult to treat due to limited approved therapeutics. To support preclinical drug development and repurposing in line with 3R principles, we p ...
Leto:
2025
Vir:
Fakulteta za farmacijo (UL FFA)
Raziskovalni podatki
Oznake:
primary MSCs;3D chondrogenesis;pellets;high-content analysis;type II collagen;immunofluorescence;
Primary cells derived from connective tissues contain mesenchymal stem/stromal cell (MSC)–like progenitors with chondrogenic potential relevant for cartilage repair. However, donor and tissue specific variability and the lack of robust, high throughput analytical methods limit their translational u ...
Leto:
2026
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
Chronic lymphocytic leukemia (CLL) is a hematological neoplasm of CD19-positive mature-appearing B lymphocytes. Despite the clinical success of targeted therapies in CLL, the development of resistance diminishes their therapeutic activity. This is also true for the Bcl-2 antagonist venetoclax. We in ...
Leto:
2022
Vir:
Fakulteta za farmacijo (UL FFA)
Izvirni znanstveni članek
Oznake:
avtofagi;odpornost na zdravila;tarčna terapija;chronic lymphocytic leukemia;autophagy;AMPK/ULK1;venetoclax;drug resistance;targeted therapy;
Continuous treatment of patients with chronic lymphocytic leukemia (CLL) with venetoclax, an antagonist of the anti-apoptotic protein Bcl-2, can result in resistance, which highlights the need for novel targets to trigger cell death in CLL. Venetoclax also induces autophagy by perturbing the Bcl-2/B ...
Leto:
2021
Vir:
Fakulteta za farmacijo (UL FFA)
Ivan Džajić,
Natalija Trunkelj,
Jernej Repas,
Maša Kandušer,
Lara Smrdel,
Stane Pajk,
Lovro Žiberna,
Irena Mlinarič-Raščan,
Boštjan Markelc,
Tim Božič,
Maša Bošnjak,
Tanja Dolinšek,
Maja Čemažar,
Katja Kološa,
Bojana Žegura,
Miha Virant,
Matic Lozinšek,
Tihomir Tomašić,
Lucija Peterlin-Mašič,
Lucija Peterlin-Mašič,
Andrej Emanuel Cotman,
Andrej Emanuel Cotman
Izvirni znanstveni članek
Oznake:
kationi;fluorescentne sonde;medicinska kemija;mitohondriji;cancer;cations;fluorescentprobes;medicinal chemistry;mitochondria;
Mitochondria-targeting moieties (MTMs) are molecular fragments designed to deliver covalently tethered functional cargo to mitochondria, providing a modular strategy for chemical biology tools, imaging agents, and mitochondria-targeted therapies. Phosphonium- or nitrogen cation-based MTMs are not in ...
Leto:
2026
Vir:
Fakulteta za farmacijo (UL FFA)