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Št. zadetkov: 17
Molecular dynamics-derived pharmacophore model explaining the nonselective aspect of KV10.1 pore blockers
Žan Toplak, Franci Merzel, Luis A. Pardo, Lucija Peterlin-Mašič, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: zaviralci kalijevih kanalčkov;molekularna dinamika;farmakofor;cancer;Eag1;hERG;KV10.1 inhibitors;molecular dynamics;pharmacophore;
The KV10.1 voltage-gated potassium channel is highly expressed in 70% of tumors, and thus represents a promising target for anticancer drug discovery. However, only a few ligands are known to inhibit KV10.1, and almost all also inhibit the very similar cardiac hERG channel, which can lead to undesir ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Lipophilic cations as mitochondria-targeting moieties: recent progress and design principles for medicinal chemistry
Ivan Džajić, Tihomir Tomašić, Luis A. Pardo, Lucija Peterlin-Mašič, Andrej Emanuel Cotman
Pregledni znanstveni članek
Oznake: assays;cations;conjugate acid-base pairs;mitochondria;sensor probes;
Mitochondria-targeting technology, in the form of (lipophilic cation)–(small molecule) conjugates, was first discussed more than 50 years ago. Since then, the triphenylphosphonium (TPP) cation has become synonymous with the concept of a mitochondria-targeting moiety (MTM). The discovery of its abili ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Discovery of K V 1.3 ion channel inhibitors
Špela Gubič, Louise Antonia Hendrickx, Žan Toplak, Maša Sterle, Steve Peigneur, Tihomir Tomašić, Luis A. Pardo, Jan Tytgat, Anamarija Zega, Lucija Peterlin-Mašič
Pregledni znanstveni članek
Oznake: KV1.3 channel;design of KV1.3 inhibitors;mitochondrial KV1.3;peptide inhibitors;small-molecule inhibitors;
The KV1.3 voltage gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treatin ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
New diarylamine KV10.1 inhibitors and their anticancer potential
Špela Gubič, Žan Toplak, Xiaoyi Shi, Jaka Dernovšek, Louise Antonia Hendrickx, Ernesto Lopes Pinheiro-Junior, Steve Peigneur, Jan Tytgat, Luis A. Pardo, Lucija Peterlin-Mašič, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: KV10.1;ionski kanali;hERG;SAR;antiproliferativno delovanje;ion channels;antiproliferative activity;
Expression of the voltage-gated potassium channel KV10.1 (Eag1) has been detected in over 70% of human cancers, making the channel a promising new target for new anticancer drug discovery. A new structural class of KV10.1 inhibitors was prepared by structural optimisation and exploration of the stru ...
Leto: 2022 Vir: Fakulteta za farmacijo (UL FFA)
Speaker Diarization For Multi-Microphone Meetings Using Only Between-Channel Differences
Jose Pardo
Video in druga učna gradiva
Oznake: computer science;speech analysis
Leto: 2006 Vir: videolectures.net
On the balanced upper chromatic number of cyclic projective planes and projective spaces
Gabriela Araujo-Pardo, György Kiss, Amanda Montejano
Izvirni znanstveni članek
Oznake: balanced rainbow-free colorings;upper chromatic number;projective planes;projective spaces;
On the balanced upper chromatic number of cyclic projective planes and projective spaces
Leto: 2015 Vir: Univerza na Primorskem (UP)
On extremal (almost) edge-girth-regular graphs
Gabriela Araujo-Pardo, György Kiss, István Porupsánszki
Izvirni znanstveni članek
Oznake: edge-girth-regular graph;cage problem;finite biaffine planes;
A k-regular graph of girth g is called an edge-girth-regular graph, or an egr-graph for short, if each of its edges is contained in exactly λ distinct g-cycles. An egr-graph is called extremal for the triple (k, g, λ) if has the smallest possible order. We prove that some graphs arising from inciden ...
Leto: 2025 Vir: Repozitorij Univerze na Primorskem (RUP)
Semicubic cages and small graphs of even girth from voltage graphs
Flor Aguilar, Gabriela Araujo-Pardo, Leah Berman
Izvirni znanstveni članek
Oznake: Graph;semicubic graph;girth;voltage graph;
A ({3, m}; g)-semicubic graph is a graph where the degree of each vertex is either 3 or m and the girth of the graph is g; if m = 3 we have a cubic graph. In this paper, we construct families of semicubic graphs of even girth and small order using two different techniques. The first technique genera ...
Leto: 2026 Vir: Repozitorij Univerze na Primorskem (RUP)
Resuscitation education science meets virtual and augmented reality: evolution from potential concept to recommendations
Nino Fijačko, Manuel Pardo Rios, Federico Semeraro, Vinay Nadkarni, Robert Greif
Kratki znanstveni prispevek
Oznake: extended reality;virtual reality;augmented reality;adult basic life support;review;
Leto: 2025 Vir: Fakulteta za zdravstvene vede (UM FZV)
Automatic detection and delineation of karst terrain depressions and its application in geomorphological mapping and morphometric analysis
Peter A. Dowd, Juan José Durán Valsero, Eulogio Pardo-Igúzquiza
Izvirni znanstveni članek
Oznake: digital relief models;karst phenomena;cartography;
Leto: 2013 Vir: dLib.si Digitalna knjižnica Slovenije
Št. zadetkov: 17
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