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Št. zadetkov: 4
Natural sources, pharmacokinetics, biological activities and health benefits of hydroxycinnamic acids and their metabolites
Matej Sova, Luciano Saso
Pregledni znanstveni članek
Oznake: diet;natural compounds;phenolic acids;hydroxycinnamic acids;metabolites;pharmacokinetic properties;biological activities;health effects;
Hydroxycinnamic acids (HCAs) are important natural phenolic compounds present in high concentrations in fruits, vegetables, cereals, coffee, tea and wine. Many health beneficial effects have been acknowledged in food products rich in HCAs; however, food processing, dietary intake, bioaccessibility a ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
Delivery strategies to improve the pharmacological efficacy of NRF2 modulators: a review
Zerrin Sezgin-Bayindir, Matej Sova, Yüksel Nilüfer, Luciano Saso
Pregledni znanstveni članek
Oznake: modulatorji Nrf2;nanomedicina;sinergija med nanomedicino in modulatorjem Nrf2;terapevtski potencial modulatorjev NRF2;kemopreventivna sredstva;zdravila za zdravljenje raka;nevrološka zdravila;oksidativni stres;signalna pot;Nrf2 modulators;nanomedicine;nanomedicine-Nrf2 modulator synergy;the therapeutic potential of NRF2 modulators;chemopreventive agents;cancer therapeutics;neurological therapeutics;oxidative stress;signaling pathway;
The NRF2/KEAP1 signaling pathway regulates the gene expression of numerous cytoprotective and detoxifying enzymes and is therefore essential for maintaining cellular redox homeostasis. Despite the increasing knowledge of NRF2 signaling complexity, dimethyl fumarate remains the sole NRF2-targeting th ...
Leto: 2025 Vir: Fakulteta za farmacijo (UL FFA)
Synthesis, in vitro antioxidant properties and distribution of a new cyanothiophene-based phenolic compound in olive oil-In-water emulsions
Sonia Losada-Barreiro, Matej Sova, Janez Mravljak, Luciano Saso, Carlos Bravo-Díaz
Izvirni znanstveni članek
Oznake: cyanothiophene scaffold;oil-in-water emulsion;distribution;interfacial concentration;drug-like properties;antioxidant;
We synthesized and determined the antioxidant activity and distribution of a new cyanothiophene-based compound, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3,5-dihydroxybenzamide (SIM-53B), in intact stripped olive oil-in-water emulsion. The in vitro antioxidant properties of SIM-53B were ev ...
Leto: 2020 Vir: Fakulteta za farmacijo (UL FFA)
Nanotechnology-based drug delivery to improve the therapeutic benefits of NRF2 modulators in cancer therapy
Zerrin Sezgin-Bayindir, Sonia Losada-Barreiro, Carlos Bravo-Díaz, Matej Sova, Julijana Kristl, Luciano Saso
Pregledni znanstveni članek
Oznake: NRF2 modulators;anticancer agents;nanoparticles;drug delivery;drug targeting;
The disadvantages of conventional anticancer drugs, such as their low bioavailability, poor targeting efficacy, and serious side effects, have led to the discovery of new therapeutic agents and potential drug delivery systems. In particular, the introduction of nano-sized drug delivery systems (NDDS ...
Leto: 2021 Vir: Fakulteta za farmacijo (UL FFA)
Št. zadetkov: 4
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