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Ligand-based pharmacophore modeling for the discovery of Na[sub]V1.7 inhibitors
Martina Piga, Peter Lukacs, Krisztina Pesti, György Várady, Zoltán Varga, Nace Zidar, Tihomir Tomašić
Izvirni znanstveni članek
Oznake: NaV1.7 inhibitors;pharmacophore model;selectivity;virtual screening;voltage-gated sodium channel;
Voltage-gated sodium channel NaV1.7 is a key mediator of electrical excitability and signal transmission in peripheral nociceptors and has emerged as a highly attractive therapeutic target for the development of novel analgesic agents. However, the development of selective NaV1.7 inhibitors has been ...
Leto: 2026 Vir: Fakulteta za farmacijo (UL FFA)
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