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Št. zadetkov: 5
Uporaba javno dostopnih podatkovnih zbirk in bioinformatičnih orodij za analizo genskega izražanja pri sistemski sklerozi
Katjuša Mrak Poljšak, Uroš Potočnik, Katja Lakota
Magistrsko delo
Oznake: fibroza;fibroblasti;pljučno tkivo;imunski sistem;epigenetika;
Izhodišča: Sistemska skleroza (SSc) je kronična sistemska avtoimunska bolezen vezivnega tkiva. Patogeneza bolezni še ni popolnoma poznana. Pogost vzrok smrti pri bolnikih s SSc je intersticijska pljučna bolezen. Naš namen je bil z uporabo javno dostopnih podatkovnih baz in bioinformatičnih orodij ug ...
Leto: 2019 Vir: Fakulteta za zdravstvene vede (UM FZV)
Verification, implementation and harmonization of automated chemiluminescent immunoassays for MPO- and PR3-ANCA detection
Manca Ogrič, Tinka Švec, Katjuša Mrak Poljšak, Polona Žigon, Alojzija Hočevar, Saša Čučnik, Saša Čučnik
Izvirni znanstveni članek
Oznake: antineutrophil cytoplasmic antibodies (ANCA);proteinase 3 (PR3);myeloperoxidase (MPO);ANCA-associated vasculitis (AAV);chemiluminescent immunoassay;likelihood ratios (LRs);
Objectives: Antineutrophil cytoplasmic antibody (ANCA) testing assists clinicians diagnose ANCA-associated vasculitis (AAV). We aimed to verify and harmonize chemiluminescent immunoassays for the detection of myeloperoxidase (MPO)- and proteinase 3 (PR3)-ANCA. Methods: An in-house ELISA, a capture E ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Haptoglobin as a novel predictor of visceral involvement and relapse in adult IgAV patients
Mitja Bajželj, Nina Visočnik, Katjuša Mrak Poljšak, Matjaž Hladnik, Katja Lakota, Katja Lakota, Alojzija Hočevar
Izvirni znanstveni članek
Oznake: hepatoglobin;IgA vasculitis;transcription data;biomarker;
Introduction: IgA vasculitis (IgAV) can present as skin-limited or systemic disease, which can be severe in adults. Predictive markers for visceral involvement are suboptimal. Considering haptoglobin's role as an acute phase reactant, we evaluated whether its differential expression in IgAV patients ...
Leto: 2025 Vir: Digitalni repozitorij raziskovalnih organizacij Slovenije
Insights into the immunological description of cryoglobulins with regard to detection and characterization in Slovenian rheumatological patients
Manca Ogrič, Tinka Švec, Katjuša Mrak Poljšak, Katja Lakota, Eva Podovšovnik, Marie Nathalie Kolopp-Sarda, Alojzija Hočevar, Saša Čučnik, Saša Čučnik
Izvirni znanstveni članek
Oznake: cryoglobulins;cryoglobulinemic vasculitis;rheumatoid factor activity;complement components;cryoglobulin detection;pre-analytical phase;
The detection of cryoglobulins (CG) used to diagnose cryoglobulemic vasculitis requires strict adherence to protocol, with emphasis on the preanalytical part. Our main objectives were to introduce a more sensitive and specific protocol for the detection of CG and to characterize CG in Slovenian pati ...
Leto: 2023 Vir: Medicinska fakulteta (UL MF)
Improved protective effect of umbilical cord stem cell transplantation on cisplatin-induced kidney injury in mice pretreated with antithymocyte globulin
Željka Večerić-Haler, Andreja Erman, Anton Cerar, Helena Motaln, Katja Kološa, Tamara Lah Turnšek, Snežna Sodin-Šemrl, Katja Lakota, Katjuša Mrak Poljšak, Špela Škrajnar, Simona Kranjc, Miha Arnol, Martina Perše
Izvirni znanstveni članek
Oznake: mesenchymal stem cells;nephrotoxicity;
Mesenchymal stem cells (MSCs) are recognised as a promising tool to improve renal recovery in experimental models of cisplatin-induced acute kidney injury. However, these preclinical studies were performed on severely immunodeficient animals. Here, we investigated whether human umbilical cord derive ...
Leto: 2016 Vir: Nacionalni inštitut za biologijo (NIB)
Št. zadetkov: 5
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