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Toll-like receptor 1 polymorphism is associated with impaired immune tolerance, dysregulated inflammatory responses to Borrelia burgdorferi, and heightened risk of post-infectious Lyme arthritis
Morgan A. Williams, Sergio A. Hernández, Sheila Arvikar, Katherine B. Sulka, Franc Strle, Christopher C. Wells, Tanja Petnicki-Ocwieja, Allen C. Steere, Klemen Strle
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Oznake: Lyme disease;Borrelia burgdorferi;toll-like receptors;innate immune tolerance;inflammation;Lyme arthritis;innate immunology;
Introduction: Clinical presentation of Lyme disease is largely due to host immune response to infection. Previously, we identified a variant (1805GG) in the TLR1 gene, a key immune sensor for Borrelia burgdorferi, which was associated with excessive inflammation and severe disease. Herein we examine ...
Leto: 2025 Vir: Repozitorij Univerze v Ljubljani (RUL)
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