Št. zadetkov: 11
Izvirni znanstveni članek
Oznake:
psihiatrija;epigenetika;samomorilno vedenje;psychiatry;epigenetics;suicidal behaviour;
Suicide is multifactorial and polygenic phenotype, affected by environmental and genetic factors. Among epigenetic mechanisms, miRNAs have been studied, but so far no very concise results exist. To overcome limitations of candidate miRNA and whole genome sequencing approaches, we created an in silic ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Doktorska disertacija
Oznake:
samomori;samomorilno vedenje;Slovenija;molekularna genetika;epigenetika;samomorilci;možgani;genom;sekvenciranje naslednje generacije;genetika, biokemična;psihiatrija;
Samomorilno vedenje je poligensko, večfaktorsko vedenje, ki prizadane ljudi širom sveta. Na samomorilno vedenje vplivajo številni biološki in zunanji dejavniki, ki jih lahko povežemo z epigenetiko. Mehanizmi in dejavniki samomorilnega vedenja kljub širokemu naboru novih dognanj niso v celoti poznani ...
Leto:
2019
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
suicidal behaviour;epigenetics;next-generation sequencing;
Objectives Epigenetic mechanisms are involved in regulation of many pathologies, including suicidal behaviour. However, the factors through which epigenetics affect suicidal behaviour are not fully understood. Methods We analysed DNA methylation of eight neuropsychiatric genes (NR3C1, SLC6A4, HTR1A, ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
motnje razpoloženja;samomor;shizofrenija;mood disorders;suicide;schizophrenia;
The global burden of psychopathologies appears to be underestimated, since the global psychiatric disorder burden is exceeding other medical burdens. To be able to address this problem more effectively, we need to better understand the etiology of psychiatric disorders. One of the hallmarks of psych ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
depresija;epigenetika;metilacija DNA;depression;epigenetics;DNA methylation;
Depressive disorder is a complex, heterogeneous disease that affects approx- imately 280 million people worldwide. Environmental, genetic, and neurobio- logical factors contribute to the depressive state. Since the nervous system is susceptible to shifts in activity of epigenetic modifiers, these al ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
eksosom;mikrookolje;vnetje;exosome;microenvironment;inflammation;
Glioblastoma is simultaneously the most common and most aggressive primary brain tumor in the central nervous system, with poor patient survival and scarce treatment options. Most primary glioblastomas reoccur and evolve radio- and chemoresistant properties which make them resistant to further treat ...
Leto:
2022
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
CSF;EVs;Slovene male suicides;epigenetics;miR-19a-3p;miR-4516;miRNA expression;micro RNA;suicidal behavior;suicide;
Suicide is an important public-health concern, with more than 700,000 people dying by suicide yearly. It is a multifactorial phenomenon, shaped by the effects of sociodemographic, environmental and biological factors. The latter two factors can be linked through epigenetic studies, which examine dif ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)
Pregledni znanstveni članek
Oznake:
Alzheimerjeva bolezen;epigenetika;metilacija DNA;Alzheimer's disease;epigenetics;DNA methylation;
There are currently no validated biomarkers which can be used to accurately diagnose Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies. Moreover, to date, only symptomatic treatments exist for this progressive neurodegenerative disorder. In the search for new ...
Leto:
2021
Vir:
Medicinska fakulteta (UL MF)
Izvirni znanstveni članek
Oznake:
anxiety;depression;epigenetics;DNA methylation;candidate genes;BDNF;COMT;SLC6A4;
Depression and anxiety are common mental disorders that often occur together. Stress is an important risk factor for both disorders, affecting pathophysiological processes through epigenetic changes that mediate gene–environment interactions. In this study, we explored two proposed models about the ...
Leto:
2023
Vir:
Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Hana Dema,
Alja Videtič,
Alja Videtič,
Katarina Kouter,
Mojca Katrašnik,
Mojca Jensterle Sever,
Andrej Janež,
Aleš Oblak,
Borut Škodlar,
Jurij Bon,
Jurij Bon
Izvirni znanstveni članek
Oznake:
program zmanjševanja stresa, ki temelji na čuječnosti;polycystic ovary syndrome;DNA methylation;mindfulness-based stress reduction program;
Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder affecting women of reproductive age. Research has shown that epigenetic alterations such as DNA methylation may play a role in the development and progression of abnormal ovarian function and metabolic disorders in PCOS. Studies ...
Leto:
2023
Vir:
Medicinska fakulteta (UL MF)