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Št. zadetkov: 55
Size distribution of extracellular vesicles in pretreatment ascites and plasma is correlated with primary treatment outcome in advanced high-grade serous carcinoma
Maruša Herzog, Ivan Verdenik, Borut Kobal, Katarina Černe, Katarina Černe
Izvirni znanstveni članek
Oznake: biomarkers;chemotherapy responce;extracellular vesicles;high-grade serous carcinoma;nanoparticle tracking analysis;resection success;treatment outcome;
o improve the treatment outcome and survival of patients with advanced high-grade serous carcinoma (HGSC), prognostic biomarkers for assessing the feasibility of complete (R0) or optimal (R1) primary cytoreductive surgery are needed. Additionally, biomarkers for predicting the response to neoadjuvan ...
Leto: 2025 Vir: Repozitorij Univerze v Ljubljani (RUL)
Higher EpCAM-positive extracellular vesicle concentration in ascites is associated with shorter progression-free survival of patients with advanced high-grade serous carcinoma
Maruša Herzog, Ivan Verdenik, Borut Kobal, Katarina Černe, Katarina Černe
Izvirni znanstveni članek
Oznake: EpCAM;HGSC (ovarian cancer);biomarkers;extracellular vesicles;personalized medicine;prognosis;
Platinum-resistant high-grade serous carcinoma (HGSC) is an incurable disease, so biomarkers that could help with timely treatment adjustments and personalized approach are extensively being sought. Tumor-derived extracellular vesicles (EVs) that can be isolated from ascites and blood of HGSC patien ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Extracellular vesicle characteristics in local fluid and plasma measured by nanoparticle tracking analysis can help differentiate high-grade serous carcinoma from benign ovarian pathology
Maruša Herzog, Ivan Verdenik, Katarina Černe, Katarina Černe, Borut Kobal, Borut Kobal
Izvirni znanstveni članek
Oznake: diagnostic biomarkers;extracellular vesicles;high-grade serous carcinoma;liquid biopsy;nanoparticle-tracking analysis;ovarian cancer;
Background: High-grade serous carcinoma (HGSC) is the most lethal of gynecological cancers in developed countries. It usually presents late with non-specific symptoms and most cases are diagnosed at an advanced stage, with 5-year overall survival being around 40%. Biomarkers for screening and early ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Analysis of ATP7A expression and ceruloplasmin levels as biomarkers in patients undergoing neoadjuvant chemotherapy for advanced high-grade serous ovarian carcinoma
David Lukanovič, Sara Polajžer, Miha Matjašič, Borut Kobal, Katarina Černe, Katarina Černe
Izvirni znanstveni članek
Oznake: ATP7A;transporter;ceruloplasmin;ovarian cancer;high-grade serous carcinoma;chemoresistance;predictive marker;
Ovarian cancer (OC), particularly high-grade serous carcinoma (HGSC), is a leading cause of gynecological cancer mortality due to late diagnosis and chemoresistance. While studies on OC cell lines have shown that overexpression of the ATP7A membrane transporter correlates with resistance to platinum ...
Leto: 2024 Vir: Repozitorij Univerze v Ljubljani (RUL)
Vpliv izbranih zdravilnih učinkovin na vezavo bilirubina na serumski albumin
Ane-Mary Arčan, Lovro Žiberna, Lovro Žiberna, Katarina Černe, Katarina Černe, Kristina Sepčić
Magistrsko delo
Oznake: bilirubin;albumin;hiperbilirubinemija;Gilbertov sindrom;kernikterus;zlatenica;hepatična encefalopatija;zaščitno delovanje;
Bilirubin je katabolni produkt hema, ki je sestavni del hemoglobina, mioglobina, citokromov, katalaze in peroksidaze. V celicah se hem s hem oksigenazami pretvarja v biliverdin in slednji z biliverdin reduktazo v bilirubin. Pri zdravih ljudeh je vrednost celokupnega bilirubina v krvi med 5 in 17 µM. ...
Leto: 2018 Vir: Biotehniška fakulteta (UL BF)
Integrating chronic inflammation and hypoxia
Sara Polajžer, David Lukanovič, Erik Škof, Borut Kobal, Katarina Černe, Katarina Černe, Katja Lakota
Izvirni znanstveni članek
Oznake: body fluids;chronic inflammation;HIF-1a;high-grade serous ovarian carcinoma;neoadjuvant chemotherapy;tumor tissue;
High-grade serous ovarian carcinoma (HGSOC) is marked by late diagnosis and chemoresistance, partly driven by chronic inflammation and hypoxia in the tumor microenvironment. Hypoxia-inducible factor 1-alpha (HIF-1a) is a key regulator of these processes; however, its spatial distribution, interactio ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
Kompleksna sestava in učinki strupa medonosne čebele - od anafilaksije do toksičnosti
Katarina Černe
Pregledni znanstveni članek
Oznake:
Leto: 2009 Vir: dLib.si Digitalna knjižnica Slovenije
Struktura prostih trgov
Katarina Černe, David Dolžan
Diplomsko delo
Oznake: matematika;finančni trgi;prosti trg;trgovci;omrežje trgovcev;
Struktura prostih trgov
Leto: 2017 Vir: Fakulteta za matematiko in fiziko (UL FMF)
Konstrukcija geometrijsko zveznih parametričnih ploskev
Katarina Černe, Marjetka Krajnc
Magistrsko delo
Oznake: matematika;geometrijska zveznost;pogoji Gn-zveznost;Bézierjeve ploskve;CAGD;
V magistrskem delu je predstavljen pojem geometrijske zveznosti parametrično podanih ploskev. Opisani so potrebni in zadostni pogoji za $G^n$-zveznost dveh ploskev vzdolž skupne krivulje ter geometrijska interpretacija $G^1$-zveznosti. V nadaljevanju so predstavljene polinomske Bézierjeve ploskv ...
Leto: 2020 Vir: Fakulteta za matematiko in fiziko (UL FMF)
Napoved rezistence na kemoterapijo na osnovi platine pri raku jajčnikov
Žan Fortuna, Katarina Černe
Diplomsko delo
Oznake: kemoterapija;rezistenca;ATPaze;ATP7A;celične linije;OAW42;PEO1;pretočna citometrija;diplomska dela;
Rak jajčnikov je izmed ginekoloških rakov najsmrtonosnejša oblika bolezni, kjer je najpogostejši serozni karcinom visokega gradusa (HGSC), ki izhaja iz epitelija na površini jajčnikov. Eden izmed glavnih razlogov za slabo prognozo je pozno odkrivanje bolezni, saj se simptomi največkrat pojavijo šele ...
Leto: 2022 Vir: Fakulteta za kemijo in kemijsko tehnologijo (UL FKKT)
Št. zadetkov: 55
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