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Homology-directed CRISPR-Cas9 correction of the KRT5 p.E475G mutation in human iPSC line from a patient with severe epidermolysis bullosa simplex
Ana Trobec, Ana Trobec, Victor Lorrain, Dusko Ilic, Karine Raymond, Mirjana Liović
Izvirni znanstveni članek
Oznake: CRISPR-Cas9;epidermolysis bullosa simplex;homology-directed repair (HDR);induced pluripotent stem cells (iPSC);isogenic control;KRTS;
Severe epidermolysis bullosa simplex is a skin fragility disorder characterized by blistering caused by cytolysis within basal keratinocytes, resulting in compromised epidermal integrity. Here we report the generation of the human induced pluripotent stem cell (hiPSC) line MLi002-A-1, an isogenic co ...
Leto: 2026 Vir: Medicinska fakulteta (UL MF)
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